Encapsulating tributyrin during enzymatic cyclodextrin synthesis improves the solubility and bioavailability of tributyrin
Encapsulating tributyrin during enzymatic cyclodextrin synthesis improves the solubility and bioavailability of tributyrin
复制标题
在酶促环糊精合成过程中封装三丁酸甘油酯可提高三丁酸甘油酯的溶解度和生物利用度
DOI：
10.1016/j.foodhyd.2020.106512
复制
发表时间：
2021-04-01
影响因子：
10.7
通讯作者：
Li, Zhaofeng
中科院分区：
文献类型：
--
作者：
Li, Caiming;Li, Zexi;Li, Zhaofeng
虽然三丁酸甘油酯对肠道健康有很大的好处，但它的感官质量不好，溶解度低，生物利用度低。微胶囊化可以提供一种避免这些限制的方法。我们之前的研究报道了一种在酶促环糊精合成过程中封装三丁酸甘油酯的新方法，本研究比较了用该方法制备的三丁酸甘油酯微胶囊（CGT）与其他常用微胶囊壁材制备的微胶囊的性能。结果表明，CGT在三丁酸甘油酯保留率和微胶囊形态方面略逊于麦芽糖糊精制备的CGT，但明显优于β -环糊精制备的CGT，这可能是由于CGT的包合空间更大。更重要的是，CGT具有最高的乳状稳定性（93.21%），并且在哺乳动物肠道模型中具有优异的三丁酸甘油酯含量控释（65.50%）。这些发现证明了CGT及其制备方法的实用性，并进一步阐明了壁材类型与微胶囊性能之间的关系。
Although tributyrin has great benefits for intestinal health, it suffers from unpleasant sensory qualities, low solubility, and low bioavailability. Microencapsulation may provide a way to avoid these limitations. Our previous study reported a new method for encapsulating tributyrin during enzymatic cyclodextrin synthesis, and this study compared the performance of tributyrin microcapsules prepared using this method (CGT) with those prepared using other common microcapsule wall materials. The results showed that CGT were slightly inferior to those prepared using maltodextrin in tests of tributyrin retention and microcapsule morphology, but significantly superior to those prepared using beta-cyclodextrin, perhaps due to greater inclusion space. More importantly, CGT had the highest emulsion stability (93.21%) and showed superior controlled release of their tributyrin content in a model of the mammalian intestine (65.50%). These findings demonstrate the utility of CGT and its preparation method, and further illuminate the relationship between wall material type and microcapsule performance.