Behavioral mediation of the relationship between psychosocial factors and HIV disease progression
Behavioral mediation of the relationship between psychosocial factors and HIV disease progression
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DOI：
10.1097/psy.0b013e318177353e
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发表时间：
2008-06-01
影响因子：
3.3
通讯作者：
Koopman, Cheryl
中科院分区：
文献类型：
--
作者：
Gore-Felton, Cheryl;Koopman, Cheryl
应对药物副作用和共病的心理和身体需求可能是压倒性的，并可能影响行为，如药物依从性，物质使用，性风险行为和运动，反过来又影响健康结果。在不同人群中进行的横断面和前瞻性研究表明，这些行为机制可能与HIV疾病进展有关。改变行为的动机通常在压力源发生后最高。然而，随着时间的推移，继续特定行为改变的动机往往受到习惯，环境影响和心理社会因素的挑战。此外，许多研究表明，行为机制可能介导心理社会变量之间的关系（例如，压力，抑郁，应对和社会支持）和艾滋病毒的疾病进展。因此，制定临床干预措施，解决这些心理社会因素，加强保护性健康行为，减少对健康造成风险的行为，可能会降低艾滋病毒/艾滋病患者的总体发病率和死亡率。
The psychological and physical demands of coping with medication side effects and comorbid illnesses can be overwhelming and may influence behaviors, such as medication adherence, substance use, sexual risk behavior, and exercise that, in turn, affect health outcomes. Cross-sectional and prospective studies among diverse populations of persons living with HIV suggest that these behavioral mechanisms may be associated with HIV disease progression. The motivation to change behavior is often highest in the immediate aftermath of a stressor. However, over time the motivation to continue a particular behavior change is often challenged by habits, environmental influences, and psychosocial factors. Furthermore, a number of studies suggest that behavioral mechanisms may mediate the relationship between psychosocial variables (e.g., stress, depression, coping, and social support) and disease progression in HIV. Thus, developing clinical interventions that address these psychosocial factors and enhance protective health behaviors and reduce behaviors that convey risk to health are likely to lessen overall morbidity and mortality among patients living with HIV/AIDS.