Synthesis using microwave irradiation and antibacterial evaluation of new N,O-acetals and N,S-acetals derived from 2-amino-1,4-naphthoquinones
Synthesis using microwave irradiation and antibacterial evaluation of new N,O-acetals and N,S-acetals derived from 2-amino-1,4-naphthoquinones
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DOI：
10.1016/j.ejmech.2013.01.010
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发表时间：
2013-05-01
影响因子：
6.7
通讯作者：
Ferreira, Vitor F.
中科院分区：
文献类型：
--
作者：
Jordao, Alessandro K.;Novais, Juliana;Ferreira, Vitor F.
本文报道了以2-氨基-1，4-萘醌为原料合成的一系列新型N，O-缩醛和N，S-缩醛(7a-o)，并对其进行了抗菌活性评价。这些化合物在微波辐射下以良好的产率获得，其中几个化合物显示出良好的抗菌谱。我们的三个生物活性2-氨基-1，4-萘醌N，O-缩醛和N，S-缩醛被鉴定为潜在的先导化合物。用一维核磁共振技术(H-1，C-13-APT)、红外光谱、元素分析和高分辨电喷雾电离质谱仪(HR-ESI-MS)对所有化合物进行了表征。(C)2013年，爱思唯尔·马森公司出版。
This paper describes a novel series of N,O-acetals and N,S-acetals (7a-o) derived from 2-amino-1,4-naphthoquinones that were synthesized and evaluated as potential antimicrobial agents. These compounds were obtained in good yields using microwave irradiation, and several of them showed promising antibacterial profiles. Three of our biologically active 2-amino-1,4-naphthoquinone N,O-acetals and N,S-acetals tested against hospital bacterial strains were identified as potential lead compounds. Characterization of all compounds was performed using one-dimensional NMR techniques (H-1, C-13-APT), IR spectra, elemental analyses and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). (C) 2013 Published by Elsevier Masson SAS.