The role of the dorsolateral prefrontal cortex in random number generation: A study with positron emission tomography
The role of the dorsolateral prefrontal cortex in random number generation: A study with positron emission tomography
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DOI：
10.1006/nimg.2000.0647
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发表时间：
2000-12-01
期刊：
影响因子：
5.7
通讯作者：
Frith, CD
中科院分区：
文献类型：
--
作者：
Jahanshahi, M;Dirnberger, G;Frith, CD
随机数生成（RNG）涉及许多执行流程。我们使用正电子发射断层扫描（PET）测量了6名志愿者的区域脑血流量（rCBF），这些志愿者以6个音调为节奏进行RNG和对照计数（COUNT）任务。这提供了RNG难度的系统变化。与COUNT相比，RNG与左侧背外侧前额叶皮层（DLPFC）、前扣带、双侧顶叶上皮层、右侧额叶下皮层以及左右小脑半球的显著激活相关。更快的RNG速率与左、右DLPFC和右顶叶上皮层区域脑血流量（rCBF）显著降低有关。左侧DLPFC的rCBF与计数得分1呈显著负相关，计数得分1是RNG期间习惯性计数的衡量标准。这些结果与RNG的网络调制模型有关；本研究是在以往经颅磁刺激和双任务范式研究的基础上发展起来的。这表明在RNG过程中；在本研究中，习惯性计数的抑制是通过左DLPFC对分布在颞上皮层的数字关联网络的调节（抑制）影响来实现的。在更快的RNG速率下，节奏性RNG的同步需求导致这种调节影响的破坏，这从左侧DLPFC的rCBF减少和更快速率下习惯性计数增加中可以明显看出。(C) 2000年学术出版社。
Random number generation (RNG) engages a number of executive processes. We used positron emission tomography (PET) to measure regional cerebral blood flow (rCBF) in six volunteers who performed RNG and a control counting (COUNT) task at six rates paced by a tone. This provided a systematic variation of difficulty of RNG. Relative to COUNT, RNG was associated with significant activation of the left dorsolateral prefrontal cortex (DLPFC), the anterior cingulate, the superior parietal cortex bilaterally, the right inferior frontal cortex, and the left and right cerebellar hemispheres. Faster rates of RNG were associated with a significant decrease in regional cerebral blood how (rCBF) in the left and right DLPFC and the right superior parietal cortex. rCBF in the left DLPFC was significantly and negatively associated with count score 1, a measure of habitual counting during RNG. These results are discussed in relation to the network modulation model of RNG; developed on the basis of our previous studies using transcranial magnetic stimulation and dual task paradigms. This suggests that during RNG;, suppression of habitual counting is achieved through the modulatory (inhibitory) influence of the left DLPFC over a number associative network distributed in the superior temporal cortex. At faster rates of RNG the synchronization demands of paced RNG result in the breakdown of this modulatory influence, which is evident from decreased rCBF in the left DLPFC and increased habitual counting at faster rates. (C) 2000 Academic Press.