Repetitive Transcranial Magnetic Stimulation of the Brain Region Activated by Motor Imagery Involving a Paretic Wrist and Hand for Upper-Extremity Motor Improvement in Severe Stroke: A Preliminary Study.
Repetitive Transcranial Magnetic Stimulation of the Brain Region Activated by Motor Imagery Involving a Paretic Wrist and Hand for Upper-Extremity Motor Improvement in Severe Stroke: A Preliminary Study.
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对涉及瘫痪手腕和手的运动想象激活的大脑区域进行重复经颅磁刺激，以改善严重中风的上肢运动：初步研究
DOI：
10.3390/brainsci13010069
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发表时间：
2022-12-29
期刊：
影响因子：
3.3
通讯作者：
Lu, Rongrong
中科院分区：
文献类型：
--
作者：
Gao, Tianhao;Hu, Yiqian;Zhuang, Jie;Bai, Yulong;Lu, Rongrong
大约三分之二的中风幸存者经历慢性上肢轻瘫;然而，治疗选择有限。重复经颅磁刺激（rTMS）可以促进中风幸存者的运动功能恢复，但其疗效存在争议。我们比较了刺激不同的目标在10例慢性脑卒中患者严重上肢运动障碍的疗效。基于运动想象的脑机接口训练与虚拟现实增强被用来诱导在想象任务期间的大脑区域中的神经活动。然后将参与者随机分配到两组：实验组（接受高频rTMS传递到较早激活的大脑区域）和对照组（接受低频rTMS传递到对侧初级运动皮层）。行为指标和扩散张量成像进行了比较前和后rTMS。干预后，两组参与者都有所改善。这项初步研究表明，在严重的上肢运动障碍的慢性脑卒中患者中，在运动想象任务中诱导特定脑区的激活并选择这些区域作为目标是可行的。需要进一步的研究来探索这种干预的有效性。
Approximately two-thirds of stroke survivors experience chronic upper-limb paresis; however, treatment options are limited. Repetitive transcranial magnetic stimulation (rTMS) can enhance motor function recovery in stroke survivors, but its efficacy is controversial. We compared the efficacy of stimulating different targets in 10 chronic stroke patients with severe upper-limb motor impairment. Motor imagery-based brain–computer interface training augmented with virtual reality was used to induce neural activity in the brain region during an imagery task. Participants were then randomly assigned to two groups: an experimental group (received high-frequency rTMS delivered to the brain region activated earlier) and a comparison group (received low-frequency rTMS delivered to the contralesional primary motor cortex). Behavioural metrics and diffusion tensor imaging were compared pre- and post rTMS. After the intervention, participants in both groups improved somewhat. This preliminary study indicates that in chronic stroke patients with severe upper-limb motor impairment, inducing activation in specific brain regions during motor imagery tasks and selecting these regions as a target is feasible. Further studies are needed to explore the efficacy of this intervention.
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DOI：
10.3389/fresc.2022.795335
发表时间：
2022
期刊：
FRONTIERS IN REHABILITATION SCIENCES
影响因子：
--
作者：
Hildesheim, Franziska E.;Silver, Alexander N.;Dominguez-Vargas, Adan-Ulises;Andrushko, Justin W.;Edwards, Jodi D.;Dancause, Numa;Thiel, Alexander
通讯作者：
Thiel, Alexander
影响因子：
2.7
作者：
DECETY, J;JEANNEROD, M;PRABLANC, C
通讯作者：
PRABLANC, C
DOI：
10.1016/j.clinph.2012.01.010
发表时间：
2012-05
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Groppa S;Oliviero A;Eisen A;Quartarone A;Cohen LG;Mall V;Kaelin-Lang A;Mima T;Rossi S;Thickbroom GW;Rossini PM;Ziemann U;Valls-Solé J;Siebner HR
通讯作者：
Siebner HR
DOI：
10.1016/j.jstrokecerebrovasdis.2022.106469
发表时间：
2022-04-11
影响因子：
2.5
作者：
Dehno, Nasrin Salehi;Kamali, Fahimeh;Jaberzadeh, Shapour
通讯作者：
Jaberzadeh, Shapour
影响因子：
5.5
作者：
FERBERT, A;PRIORI, A;MARSDEN, CD
通讯作者：
MARSDEN, CD