Polymorphism in the interleukin-1 gene complex and spontaneous preterm delivery
Polymorphism in the interleukin-1 gene complex and spontaneous preterm delivery
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DOI：
10.1067/mob.2002.122407
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发表时间：
2002-07-01
影响因子：
9.8
通讯作者：
Witkin, SS
中科院分区：
文献类型：
--
作者：
Genç, MR;Gerber, S;Witkin, SS
目的：我们研究了早产与白细胞介素-1 β基因+3953位点多态性之间的关系，研究设计：这是一项病例对照研究，涉及52例妊娠，导致自发性早产前34周的妊娠和197例妊娠，导致在足月分娩。通过聚合酶链反应和限制性片段长度多态性分析确定多态性。结果：非洲裔胎儿携带IL 1B +3953等位基因1纯合子与早产风险相关（P = 0.033）。研究发现携带IL 1 RN等位基因2的西班牙裔胎儿发生早产、胎膜早破和随后早产的风险增加（P = 0.021;比值比，6.5; 95% CI，1.25-37.7）。在非洲和西班牙裔人群中，自发性早产分别与胎儿携带IL 1B +3953*1和IL 1 RN *2等位基因有关。
OBJECTIVE: We examined the association between preterm delivery and polymorphisms at position +3953 of the interleukin-1beta gene (IL1B+3953) and in intron 2 of the interleukin-1 receptor antagonist gene (IL1RN).STUDY DESIGN: This was a case-control study that involved 52 pregnancies that resulted in spontaneous preterm delivery before 34 weeks of gestation and 197 pregnancies that resulted in birth at term. Polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism analysis.RESULTS: Homozygous carriage of IL1B+3953 allele 1 by fetuses of African descent was associated with a risk of preterm delivery (P = .033). Fetuses of Hispanic descent that carried IL1RN allele 2 were found to be at an increased risk for preterm premature rupture of membranes and subsequent preterm delivery (P = .021; odds ratio, 6.5; 95% CI, 1.25-37.7).CONCLUSION: There are associations of spontaneous preterm delivery with the fetal carriage of IL1B+3953*1 and IL1RN*2 alleles in African and Hispanic populations, respectively.