The clinical characteristics of new daily persistent headache
The clinical characteristics of new daily persistent headache
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DOI：
10.1046/j.1468-2982.2002.00326.x
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发表时间：
2002-02-01
期刊：
影响因子：
4.9
通讯作者：
Rozen, TD
中科院分区：
文献类型：
--
作者：
Li, D;Rozen, TD
新发每日持续性头痛（NDPH）是慢性每日性头痛的一个亚型。关于NDPH的文献很少，其真正的病因尚不清楚。从1997年8月至2000年5月，从杰弗逊头痛中心的计算机数据库中进行回顾性图表回顾，以使用Silberstein等人的标准确定NDPH患者。40名女性和16名男性已被确认身份。发病年龄从12岁到78岁不等。发病的高峰年龄是女性的第二和第三个十年和男性的第五个十年。82%的患者能够准确地指出他们的头痛是从哪里开始的。30%的发病与感染或流感样疾病有关。38%的患者有头痛病史，29%的患者有头痛家族史。每日头痛持续时间为1.5 h ~ 24 h；79%是连续的。68%的患者出现恶心，60%的患者出现畏光，61%的患者出现声音恐惧症，55%的患者出现头晕。除了爱泼斯坦-巴尔病毒抗体滴度外，所有患者的实验室检测和神经影像学检查均正常，在7名接受检测的患者中，有71%的患者抗体滴度呈阳性，表明过去感染过。NDPH似乎是一种以女性为主的疾病，其特征是持续的每日头痛并伴有偏头痛症状。超过80%的患者能说出头痛开始的确切日期。三分之一的患者出现NDPH并伴有流感样疾病。
New daily persistent headache (NDPH) is a subtype of chronic daily headache. The literature on NDPH is scant and its true aetiology is unknown. A retrospective chart review was carried out from a computerized database at the Jefferson Headache Centre from August 1997 to May 2000 to identify patients with NDPH using the Silberstein et al. criteria. Forty women and 16 men were identified. Age of onset ranged from 12 to 78 years. The peak age of onset was the second and third decade in women and the the fifth decade in men. Eighty-two per cent of patients were able to pinpoint the exact clav their headache started. Onset occurred in relation to an infection or flu-like illness in 30%. A prior headache history was found in 38% of patients, A family history of headache was documented in 29%. The duration of daily headache ranged from 1.5 h to 24 h; 79% were continuous. Nausea occurred in 68% of patients, photophobia in 60%, phonophobia in 61%, and lightheadedness in 55%. Laboratory testing and neuroimaging in all patients was normal except for Epstein-Barr virus antibody titres, which were positive in 71% of seven patients tested, representing past infection. NDPH appears to be a female-predominant disorder, marked by a continuous daily headache with associated migrainous symptoms. Over 80% of patients could state the exact date their headache began. One-third of patients developed NDPH with a flu-like illness.