Telomeric silencing of an open reading frame in Saccharomyces cerevisiae
Telomeric silencing of an open reading frame in Saccharomyces cerevisiae
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DOI：
10.1534/genetics.106.058420
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发表时间：
2006-06-01
期刊：
影响因子：
3.3
通讯作者：
Kaback, David B.
中科院分区：
文献类型：
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作者：
Barton, Arnold B.;Kaback, David B.
最末端的一号染色体开放阅读框因天然的端粒位置效应而沉默。发现YAR073W/IAM1在sir3突变体中以及当与其相邻的端粒被移除时，其转录水平会高得多。这些结果表明端粒在沉默实际基因中起作用。
The endmost chromosome I ORF is silenced by a natural telomere position effect. YAR073W/IAM1 was found to be transcribed at much higher levels in sir3 mutants and when its adjacent telomere was removed from it. These results suggest that telomeres play a role in silencing actual genes.