Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats
Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats
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DOI：
10.1007/s11010-009-0063-z
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发表时间：
2009-07-01
影响因子：
4.3
通讯作者：
Moghadasian, Mohammed H.
中科院分区：
文献类型：
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作者：
Abdullah, Mohammad M.;Riediger, Natalie N.;Moghadasian, Mohammed H.
我们研究了高果糖 (HF) 饮食对 Sprague-Dawley 大鼠心血管风险的影响。 12 只大鼠被随机分配接受标准食物或 HF 饮食，为期 20 周。心力衰竭组的收缩压、循环胰岛素、总胆固醇和三酰甘油水平显着升高。主动脉切片看起来正常，但心力衰竭组的肝切片显示脂质沉积、轻度炎症和胆汁色素沉着。 HF 组的肝脏样本显示出明显更高的总脂质水平和脂肪酸谱的变化。磷脂组分中 16:0、cis-9-18:2、cis-11-20:1、cis-13-20:1、cis-11-20:2 和 24:0 的水平显着升高。在非酯化脂肪酸部分中发现 cis-11-18:1、cis-9-18:2 和 cis-11-20:1 水平较低，而 16:1、cis-9-18:1 和 cis-13-20:1 水平升高。高频喂养导致某些炎症生物标志物的血浆水平显着降低。随着时间的推移，HF 摄入可能会对大鼠的心血管健康和肝功能产生负面影响。
We investigated the effects of a high-fructose (HF) diet on cardiovascular risks in Sprague-Dawley rats. Twelve rats were randomly assigned to standard chow or HF diet for 20 weeks. Systolic blood pressure and circulating insulin, total cholesterol, and triacylglycerol levels were significantly higher in the HF group. Aortic sections appeared normal, but liver sections from the HF group showed lipid accretion, mild inflammation, and bile pigmentation. Liver samples from the HF group showed significantly higher total lipid levels and changes in fatty acid profile. Levels of 16:0, cis-9-18:2, cis-11-20:1, cis-13-20:1, cis-11-20:2 and 24:0 were significantly raised in the phospholipid fraction. Lower levels of cis-11-18:1, cis-9-18:2, and cis-11-20:1 and increased levels of 16:1, cis-9-18:1, and cis-13-20:1 were found in the non-esterified fatty acid fraction. HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats.