Photothermal response of tissue phantoms containing multi-walled carbon nanotubes.
Photothermal response of tissue phantoms containing multi-walled carbon nanotubes.
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DOI：
10.1115/1.3212100
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发表时间：
2010-04
期刊：
影响因子：
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通讯作者：
Saugata Sarkar;Jessica Fisher;Christopher G. Rylander;M. Rylander
中科院分区：
文献类型：
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作者：
Saugata Sarkar;Jessica Fisher;Christopher G. Rylander;M. Rylander
在激光治疗之前将多壁碳纳米管（MWNT）包含到组织中具有通过提供更大和更受控的热沉积来增强癌症治疗的选择性和有效性的潜力。本研究的目的是调查的光学和热响应的组织代表性幻影含有多壁碳纳米管的光辐射。由藻酸钠产生直径为20 mm、厚度为1 mm的组织代表性体模。在将MWNTs（长度900 nm，直径40-60 nm）包含在体模中之后，使用透射电子显微镜观察MWNTs的分布。一个主要的，均匀分散和随机取向的分布的多壁碳纳米管观察到一个罕见的多壁碳纳米管集群或结块的存在。为了表征多壁碳纳米管（MWNT）包裹体对塑料光学性质的影响，用分光光度计在200-1400 nm波长范围内测量了含有和不含有MWNT包裹体塑料的透射光谱和反射光谱。包括多壁碳纳米管的phantomy显着增强了整个波长范围内的光吸收，证明了减少的透射率和反射率相比，phantomy没有多壁碳纳米管。为了评估与具有和不具有MWNT的体模的激光照射相关的时空温度分布，使用热电偶在离入射激光束的中心的离散径向距离处测量温度。在所有的测量位置，与没有MWNTs的Phantomy相比，含有MWNTs的Phantomy的温度升高速率和峰值温度要大得多。总之，多壁碳纳米管列入组织幻影增加光吸收和温度升高，这可能使更有效的光热疗法的人类疾病利用激光。
Inclusion of multi-walled carbon nanotubes (MWNTs) into tissue prior to laser therapy has the potential to enhance the selectivity and effectiveness of cancer therapy by providing greater and more controlled thermal deposition. The purpose of this study was to investigate the optical and thermal response of tissue representative phantoms containing MWNTs to optical radiation. Tissue representative phantoms 20 mm in diameter and 1 mm in thickness were created from sodium alginate. Following the inclusion of MWNTs (900 nm in length, 40-60 nm in diameter) in phantoms, the distribution of MWNTs was observed using transmission electron microscopy. A predominantly, evenly dispersed and randomly oriented distribution of MWNTs was observed with a rare presence of MWNT clustering or clumping. In order to characterize the response of MWNT inclusion on optical properties of phantoms, the transmittance and reflectance spectra of phantoms with and without MWNT inclusion were measured with a spectrophotometer over a wavelength range of 200-1400 nm. Inclusion of MWNTs in phantoms dramatically enhanced light absorption across the entire wavelength range as evidenced by a diminished transmittance and reflectance compared with phantoms without MWNTs. In order to evaluate the spatiotemporal temperature distribution associated with laser irradiation of phantoms with and without MWNTs, the temperature was measured at discrete radial distances from the center of the incident laser beam using thermocouples. The rate of temperature increase and peak temperature for phantoms containing MWNTs was much greater compared with phantoms without MWNTs at all measurement locations. In conclusion, MWNT inclusion in tissue phantoms increases the optical absorption and temperature elevation, which may enable more effective photothermal therapies of human disease utilizing lasers.