Unified Huntington's disease rating scale: Reliability and consistency
Unified Huntington's disease rating scale: Reliability and consistency
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DOI：
10.1002/mds.870110204
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发表时间：
1996-03-01
影响因子：
8.6
通讯作者：
Kremer, B
中科院分区：
文献类型：
--
作者：
Kieburtz, K;Penney, JB;Kremer, B
统一亨廷顿病评定量表 (UHDRS) 是一种临床评定量表，用于评估 HD 临床表现和能力的四个领域：运动功能、认知功能、行为异常和功能能力。我们评估了四个领域的内部一致性和相互关联性，并检查了评级随时间的变化。我们还对运动评估进行了参与者间可靠性研究。我们发现 UHDRS 的每个领域都存在高度的内部一致性，并且总行为评分之间存在显着的相互相关性，运动评分具有极好的评分者间可靠性。我们有限的纵向数据库表明，UHDRS 可能有助于追踪 HD 临床特征随时间的变化。 UHDRS 评估 HD 的相关临床特征，似乎适合在临床研究期间重复给药。
The Unified Huntington's Disease Rating Scale (UHDRS) was developed as a clinical rating scale to assess four domains of clinical performance and capacity in HD: motor function, cognitive function, behavioral abnormalities, and functional capacity. We assessed the internal consistency and the intercorrelations for the four domains and examined changes in ratings over time. We also performed an interrater reliability study of the motor assessment. We found there was a high degree of internal consistency within each of the domains of the UHDRS and that there were significant intercorrelations between total behavioral score, There was an excellent degree of interrater reliability for the motor scores. Our limited longitudinal database indicates that the UHDRS may be useful for tracking changes in the clinical features of HD over time. The UHDRS assesses relevant clinical features of HD and appears to be appropriate for repeated administration during clinical studies.