Relationships between the Serum Cholesterol Levels, Production of Monocyte Proinflammatory Cytokines and Long-term Prognosis in Patients with Chronic Heart Failure
Relationships between the Serum Cholesterol Levels, Production of Monocyte Proinflammatory Cytokines and Long-term Prognosis in Patients with Chronic Heart Failure
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DOI：
10.2169/internalmedicine.53.2672
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发表时间：
2014-01-01
影响因子：
1.2
通讯作者：
Shimizu, Wataru
中科院分区：
文献类型：
--
作者：
Nakagomi, Akihiro;Seino, Yoshihiko;Shimizu, Wataru
目的 低血清胆固醇与慢性心力衰竭（CHF）患者的不良预后相关。然而，CHF患者血清胆固醇水平、单核细胞促炎细胞因子的产生与长期预后之间的关系仍不清楚。 方法对95例未接受他汀类药物治疗、平均左心室射血分数为26.0+/-6.0%的CHF患者进行检查。分离外周血单核细胞（PBMC），测量单核细胞肿瘤坏死因子（TNF）-α和白细胞介素（IL）-6的产生并表示为平均值+/-SD（pg/mL/10（6）PBMC）。结果发现单核细胞TNF-α和IL-6的产生显着且 与血清低密度脂蛋白 (LDL) 胆固醇水平呈负相关（TNF-α：r=-0.515，p
Objective Low serum cholesterol is associated with a poor prognosis in patients with chronic heart failure (CHF). However, the relationships between the serum cholesterol level, production of monocyte proinflammatory cytokines and long-term prognosis in CHF patients remain unclear.Methods A total of 95 CHF patients who had not been treated with statins and had a mean left ventricular ejection fraction of 26.0 +/- 6.0% were examined. Peripheral blood mononuclear cells (PBMCs) were isolated, and the production of monocyte tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 was measured and expressed as the mean +/- SD (pg/mL/10(6) PBMCs).Results The production of monocyte TNF-alpha and IL-6 was found to be significantly and negatively associated with the serum low-density lipoprotein (LDL)-cholesterol level (TNF-alpha: r=-0.515, p