Genetics of sarcoidosis: candidate genes and genome scans.
Genetics of sarcoidosis: candidate genes and genome scans.
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DOI：
10.1513/pats.200607-141jg
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发表时间：
2007-01-01
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影响因子：
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通讯作者：
Rybicki, Benjamin A
中科院分区：
文献类型：
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作者：
Iannuzzi, Michael C;Rybicki, Benjamin A
人类白细胞抗原II类等位基因关联和结节病的T细胞受体β链偏向提示在遗传易感宿主中存在特定的致病抗原暴露。结节病的病因一直难以捉摸，但遗传学提供了为数不多的有希望加深我们理解的途径之一。我们回顾了用于识别与结节病相关的基因的关联研究和基因组扫描。
Human leukocyte antigen class II allele associations and T-cell receptor beta chain bias in sarcoidosis suggest a specific disease-triggering antigen exposure in a genetically susceptible host. The cause of sarcoidosis has been elusive, but genetics provides one of the few promising avenues to further our understanding. We review the association studies and genome scans used to identify the genes involved in sarcoidosis.