Differential effect of unfractionated heparin and low molecular weight heparin on intravascular tissue factor pathway inhibitor: evidence for a difference in antithrombotic action
Differential effect of unfractionated heparin and low molecular weight heparin on intravascular tissue factor pathway inhibitor: evidence for a difference in antithrombotic action
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DOI：
10.1046/j.1365-2141.1998.00770.x
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发表时间：
1998-06-01
影响因子：
6.5
通讯作者：
Bendz, B
中科院分区：
文献类型：
--
作者：
Hansen, JB;Sandset, PM;Bendz, B
组织因子途径抑制剂 (TEPI) 是组织因子 (TF) 诱导的凝血的有效抑制剂，其在肝素后血浆中增加数倍，并且被认为对肝素的抗血栓作用有显着贡献。在本研究中，我们研究了皮下（s.c.）给予低分子量肝素（LMWH）依诺肝素与连续静脉注射相比是否对血管内 TFPI 池有不同的影响。输注普通肝素（UFH）。 18 名健康男性志愿者被随机分配接受连续静脉注射。输注 UFH（初始 450 U/kg/24h，n=6）或皮下注射每日一次 LMWH 治疗（依诺肝素，1.5 mg/kg，n=12），持续 72 小时。 5000 TCT UFH i.o. 推注导致血浆游离 TEPI 抗原 (TFPI Ag) 增加 8-13 倍，随后逐渐减少 (81 +/- 4%，P
Tissue factor pathway inhibitor (TEPI) is a potent inhibitor of tissue factor (TF)-induced blood coagulation, which is increased several-fold in post-heparin plasma and thought to contribute significantly to the antithrombotic action of heparin. In the present study we investigated whether subcutaneous (s.c.) administration of a low molecular weight heparin (LMWH), enoxaparin, had a different effect on intravascular pools of TFPI compared with continuous i.o. infusion of unfractionated heparin (UFH). 18 healthy male volunteers were randomly assigned to continuous i.v. infusion with UFH (initially 450 U/kg/24h, n=6) or to s.c. treatment with LMWH once daily (enoxaparin, 1.5 mg/kg, n=12) for 72 h. A bolus injection of 5000 TCT UFH i.o. caused an 8-13-fold increase in plasma-free TEPI antigen (TFPI Ag), followed by a progressive decrease (81 +/- 4%, P