Copper(I)/DDQ-Mediated Double-Dehydrogenative Diels-Alder Reaction of Aryl Butenes with 1,4-Diketones and Indolones
Copper(I)/DDQ-Mediated Double-Dehydrogenative Diels-Alder Reaction of Aryl Butenes with 1,4-Diketones and Indolones
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铜(I)/DDQ介导的芳基丁烯与1,4-二酮和吲哚酮的双脱氢狄尔斯-阿尔德反应
DOI：
10.1021/acs.orglett.0c02486
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Zhou Ling
中科院分区：
文献类型：
--
作者：
Xu Wen-Lei;Hu Wei;Zhao Wei-Ming;Wang Min;Chen Jie;Zhou Ling
首次建立了铜(I)/DDQ介导的简单丁烯与1，4-二酮和吲哚的双脱氢Diels-Alder(DDDA)反应。这一策略基于未预官能化原料的串联双脱氢/Diels-Alder反应，在一个催化体系中，通过四重惰性C(SP3)-H键的活化，原位生成了双烯和双烯亲和体。
A copper(I)/DDQ-mediated double-dehydrogenative Diels–Alder (DDDA) reaction of simple butenes with 1,4-diketones and indolones has been established for the first time. This strategy is based on a tandem double-dehydrogenation/Diels–Alder reaction from nonprefunctionalized starting materials, in which both a diene and dienophile were in situ generated via activation of fourfold inert C(sp3)–H bonds in one catalytic system.