A review of research on salivary biomarkers for oral cancer detection.
A review of research on salivary biomarkers for oral cancer detection.
复制标题
对口腔癌检测的唾液生物标志物的研究综述。
DOI：
10.1186/2001-1326-3-3
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发表时间：
2014-02-24
影响因子：
10.6
通讯作者：
Wright J
中科院分区：
文献类型：
--
作者：
Cheng YS;Rees T;Wright J
使用唾液进行疾病诊断和健康监测是一种很有前途的方法，因为收集唾液相对容易且非侵入性。在过去的二十年里，使用唾液生物标志物专门用于早期癌症检测已经吸引了很多研究兴趣，特别是对于发生在口腔和口咽部的癌症，其五年生存率（62%）仍然是所有主要人类癌症中最低的。超过90%的口腔癌是口腔鳞状细胞癌（OSCC），标准的检测方法是由口腔保健专业人员进行全面的临床检查。尽管口腔很容易进入，但大多数OSCC直到晚期才被诊断出来，这被认为是生存率低的主要原因，并指出迫切需要临床诊断辅助工具来早期发现OSCC。因此，许多研究工作一直致力于研究口腔鳞状细胞癌的潜在唾液生物标志物，文献中已报道了100多种此类生物标志物。然而，一些重要的问题和挑战已经出现，需要解决方案和进一步的研究，以找到可靠的口腔鳞状细胞癌唾液生物标志物的临床应用。这篇综述文章提供了截至2013年秋季报告的潜在OSCC唾液生物标志物的最新列表，并讨论了这些新出现的问题。通过提高研究人员和临床医生对这些问题的认识，人们希望能够很快找到可靠，特异和敏感的唾液生物标志物，不仅用于早期OSCC检测，而且用于检测其他类型的癌症，甚至用于监测非癌性疾病活动。
Using saliva for disease diagnostics and health surveillance is a promising approach as collecting saliva is relatively easy and non-invasive. Over the past two decades, using salivary biomarkers specifically for early cancer detection has attracted much research interest, especially for cancers occurring in the oral cavity and oropharynx, for which the five-year survival rate (62%) is still one of the lowest among all major human cancers. More than 90% of oral cancers are oral squamous cell carcinoma (OSCC) and the standard method for detection is through a comprehensive clinical examination by oral healthcare professionals. Despite the fact that the oral cavity is easily accessible, most OSCCs are not diagnosed until an advanced stage, which is believed to be the major reason for the low survival rate, and points to the urgent need for clinical diagnostic aids for early detection of OSCC. Thus, much research effort has been dedicated to investigating potential salivary biomarkers for OSCC, and more than 100 such biomarkers have been reported in the literature. However, some important issues and challenges have emerged that require solutions and further research in order to find reliable OSCC salivary biomarkers for clinical use. This review article provides an up-to-date list of potential OSCC salivary biomarkers reported as of the fall of 2013, and discusses those emerging issues. By raising the awareness of these issues on the part of both researchers and clinicians, it is hoped that reliable, specific and sensitive salivary biomarkers may be found soon—and not only biomarkers for early OSCC detection but also for detecting other types of cancers or even for monitoring non-cancerous disease activity.