Functions of the CXC ligand family in the pancreatic tumor microenvironment
Functions of the CXC ligand family in the pancreatic tumor microenvironment
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DOI：
10.1016/j.pan.2018.07.011
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发表时间：
2018-10-01
期刊：
影响因子：
3.6
通讯作者：
He, Hong
中科院分区：
文献类型：
--
作者：
Lee, Nien-Hung;Nikfarjam, Mehrdad;He, Hong
治疗抵抗是胰腺癌预后差、生存率低的主要原因。肿瘤进展是一个复杂的过程，依赖于肿瘤和肿瘤微环境(TME)之间的相互作用。趋化因子CXCL家族的成员存在于胰腺的TME中，似乎在调节PC的进展中起着至关重要的作用。由于胰腺肿瘤与TME和PC干细胞(CSCs)相互作用，确定CXCL家族特定成员的作用对于改进治疗方法的开发至关重要。本文重点介绍了CXCL在胰腺肿瘤与其间质的相互作用中的作用，以及在CSC表型中的作用，这些表型可用于识别潜在的治疗靶点。(C)2018年IAP和EPC。爱思唯尔出版，版权所有。
Therapeutic resistance is the major contributor to the poor prognosis of and low survival from pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions between the tumor and the tumor microenvironment (TME). Members of the CXCL family of chemokines are present in the pancreatic TME and seem to play a vital role in regulating PC progression. As pancreatic tumors interact with the TME and with PC stem cells (CSCs), determining the roles of specific members of the CXCL family is vital to the development of improved therapies. This review highlights the roles of selected CXCLs in the interactions between pancreatic tumor and its stroma, and in CSC phenotypes, which can be used to identify potential treatment targets. (C) 2018 IAP and EPC. Published by Elsevier B.V. All rights reserved.