Postnatal Serum Insulin-Like Growth Factor I and Retinopathy of Prematurity in Latin American Infants.
Postnatal Serum Insulin-Like Growth Factor I and Retinopathy of Prematurity in Latin American Infants.
复制标题
拉丁美洲婴儿产后血清胰岛素样生长因子 I 和早产儿视网膜病变。
DOI：
10.1080/09286586.2020.1812090
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发表时间：
2021
影响因子：
1.8
通讯作者：
Binenbaum,Gil
中科院分区：
文献类型：
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作者：
deAlbaCampomanes,AlejandraG;EspinozaNavarro,Judith;Shaffer,James;Ying,Gui-Shuang;Zepeda-Romero,LuzConsuelo;González-Bernal,Cesareo;Gutierrez-Padilla,JoséAlfonso;Schbib,VaninaLaura;Galan,MariaMarta;Binenbaum,Gil
在新兴经济体国家，识别早产儿视网膜病变（ROP）的高危婴儿是复杂的，因为缺乏传统风险因素的婴儿，如低出生体重（BW）和小胎龄（GA），仍然会发展为严重的ROP。在发达国家，潜在的生物标志物，如血清胰岛素样生长因子1（IGF-1）和出生后体重缓慢增加，已被确定为ROP的良好预测因子。我们试图确定IGF-1水平和ROP之间的关系，在两个拉丁美洲国家的疾病负担仍然显着。MethodsProspective队列研究的婴儿在瓜达拉哈拉，墨西哥和拉普拉塔，阿根廷。从出生到出院或40周的月经后年龄（PMA），每周进行滤纸血斑IGF-1测定。结果112名婴儿的中位体重为1412 g（范围为620 g-2390 g），中位GA为33周（范围为25-37周）。有没有显着差异IGF-1之间的婴儿谁开发ROP和那些谁没有。结论低IGF-1与ROP在这些婴儿。在拉丁美洲，ROP和IGF-1之间缺乏相关性，这支持了以下观察结果，即基于生长的预测模型在这种情况下表现不佳，在这种情况下，更成熟的婴儿仍然会发生严重的ROP。
PurposeIdentifying at-risk infants for retinopathy of prematurity (ROP) is complex in countries with emerging economies as infants that lack conventional risk factors, such as low birth weight (BW) and young gestational age (GA), still go on to develop severe ROP. Potential biomarkers, like serum insulin-like growth factor 1 (IGF-1) and slow postnatal weight gain, have been identified as good predictors for ROP in developed countries. We sought to determine the relationship between IGF-1 levels and ROP in two Latin American countries where the burden of disease is still significant.MethodsProspective cohort study of infants in Guadalajara, Mexico and La Plata, Argentina. Filter-paper bloodspot IGF-1 assays were performed weekly from birth until hospital discharge or 40 weeks’ postmenstrual age (PMA).Results112 infants were studied with a median BW of 1412 g (range 620 g-2390 g) and a median GA of 33 weeks (range 25–37). There was no significant difference in IGF-1 between infants who developed ROP and those who did not.ConclusionLow IGF-1 was not associated with ROP in these infants. The lack of an association between ROP and IGF-1 in Latin America supports the observation that growth-based predictive models do not perform as well in this setting where more mature babies still develop severe ROP.