Dynamic coordination of the perirhinal cortical neurons supports coherent representations between task epochs
Dynamic coordination of the perirhinal cortical neurons supports coherent representations between task epochs
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DOI：
10.1038/s42003-020-01129-3
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发表时间：
2020-07-30
影响因子：
5.9
通讯作者：
Hirokawa, Junya
中科院分区：
文献类型：
--
作者：
Ohnuki, Tomoya;Osako, Yuma;Hirokawa, Junya
皮层神经元在不同计算的多个任务时期表现出不同的放电模式。最近的研究表明，这种独特的模式是实现计算灵活性的动态群体代码的基础，而某些皮层区域的神经元往往表现出跨时期的连贯放电模式。为了了解相干单神经元代码如何有助于动态群体代码，我们分析了大鼠嗅周皮层（PRC）的神经反应，在两个可选的强迫选择任务的提示和奖励时期。我们发现PRC神经元在这些时期之间经常编码相反的选择方向。通过使用主成分分析作为群体水平分析，我们确定了与每个时期相关的神经子空间，这反映了神经元之间的协调。线索和奖励时代共享的神经尺寸的选择方向一致的歧视。有趣的是，这些维度是由单个神经元动态变化的贡献支持的。这些结果证明了相干单神经元表示在其对群体代码的贡献中的异质性。Tomoya Ohnuki等人的研究表明，大鼠嗅周皮层中的单个神经元在提示和奖励时期对选择方向进行了一致编码。单个神经元还显示了这些时期之间对群体编码的动态变化贡献，这表明它们灵活地协调以支持与不同时期相关的计算，同时保持时间上的连贯表示。
Cortical neurons show distinct firing patterns across multiple task epochs characterized by different computations. Recent studies suggest that such distinct patterns underlie dynamic population code achieving computational flexibility, whereas neurons in some cortical areas often show coherent firing patterns across epochs. To understand how coherent single-neuron code contributes to dynamic population code, we analyzed neural responses in the rat perirhinal cortex (PRC) during cue and reward epochs of a two-alternative forced-choice task. We found that the PRC neurons often encoded the opposite choice directions between those epochs. By using principal component analysis as a population-level analysis, we identified neural subspaces associated with each epoch, which reflected coordination across the neurons. The cue and reward epochs shared neural dimensions where the choice directions were consistently discriminated. Interestingly, those dimensions were supported by dynamically changing contributions of the individual neurons. These results demonstrated heterogeneity of coherent single-neuron representations in their contributions to population code. Tomoya Ohnuki et al. show that individual neurons in the rat perirhinal cortex coherently encoded choice directions across cue and reward epochs. Individual neurons also displayed dynamically changing contributions to population encodings between these epochs, suggesting that they flexibly coordinate to support computations associated with different epochs while holding temporally coherent representations.