A Small Protein but with Diverse Roles: A Review of EsxA in Mycobacterium-Host Interaction.
A Small Protein but with Diverse Roles: A Review of EsxA in Mycobacterium-Host Interaction.
复制标题
作者：
Bao Y;Wang L;Sun J
作为ESX-1分泌系统的主要效应者，EsxA对结核分枝杆菌(Mtb)和海洋分枝杆菌(Mm)等致病分枝杆菌的毒力至关重要。EsxA具有酸性的pH依赖的膜通透性，通过介导分枝杆菌从吞噬小体逃逸和移位到胞浆进行细胞内复制而发挥重要作用。此外，EsxA作为一种有效的T细胞抗原和强大的免疫调节因子来调节宿主的免疫反应。EsxA与多种细胞蛋白相互作用，刺激多种信号通路，如坏死、凋亡、自噬和抗原递呈。有趣的是，EsxA和其他分枝杆菌因子的表达和分泌是相互依赖的，这大大增加了剖析EsxA和其他因子在分枝杆菌-宿主相互作用中的确切作用的复杂性。本文对EsxA在分枝杆菌感染中的作用和功能的研究现状进行了综述，并对其面临的挑战和未来的研究方向进行了讨论。
As a major effector of the ESX-1 secretion system, EsxA is essential for the virulence of pathogenic mycobacteria, such as Mycobacterium tuberculosis (Mtb) and Mycobacterium marinum (Mm). EsxA possesses an acidic pH-dependent membrane permeabilizing activity and plays an essential role by mediating mycobacterial escape from the phagosome and translocation to the cytosol for intracellular replication. Moreover, EsxA regulates host immune responses as a potent T-cell antigen and a strong immunoregulator. EsxA interacts with multiple cellular proteins and stimulates several signal pathways, such as necrosis, apoptosis, autophagy, and antigen presentation. Interestingly, there is a co-dependency in the expression and secretion of EsxA and other mycobacterial factors, which greatly increases the complexity of dissecting the precise roles of EsxA and other factors in mycobacterium–host interaction. In this review, we summarize the current understandings of the roles and functions of EsxA in mycobacterial infection and discuss the challenges and future directions.
登录
查看更多内容
影响因子：
5.2
作者：
Bao Y;Wang L;Sun J
通讯作者：
Sun J
影响因子：
7.3
作者：
Amaral EP;Riteau N;Moayeri M;Maier N;Mayer-Barber KD;Pereira RM;Lage SL;Kubler A;Bishai WR;D'Império-Lima MR;Sher A;Andrade BB
通讯作者：
Andrade BB
影响因子：
4.8
作者：
Boggaram, Vijay;Gottipati, Koteswara R.;Samten, Buka
通讯作者：
Samten, Buka
影响因子：
9
作者：
通讯作者：
--
影响因子：
6.7
作者：
Chatterjee S;Dwivedi VP;Singh Y;Siddiqui I;Sharma P;Van Kaer L;Chattopadhyay D;Das G
通讯作者：
Das G