Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer
Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer
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DOI：
10.1007/s00702-012-0773-3
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发表时间：
2012-08-01
影响因子：
3.3
通讯作者：
Sommer, Claudia
中科院分区：
文献类型：
--
作者：
Geis, Christian;Gruenewald, Benedikt;Sommer, Claudia
僵人综合征伴抗两性肽自身抗体，其特征是肌肉僵硬、痉挛和焦虑，这是一个不太受重视的核心症状。在这里，我们报道了在鞘内应用来自一名患者的纯化的抗amphiphysin的免疫球蛋白g抗体诱导大鼠的焦虑行为。免疫染色显示抗amphiphysin抗体结合与焦虑障碍相关的大脑结构，如杏仁核。我们提出，抗体介导的两性肽缺乏可能通过突触前gaba能通路失调来解释僵硬人综合征的焦虑行为。
Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.