Dermatologic Events Associated with the Anti-CCR4 Antibody Mogamulizumab: Characterization and Management.
Dermatologic Events Associated with the Anti-CCR4 Antibody Mogamulizumab: Characterization and Management.
复制标题
DOI：
10.1007/s13555-021-00624-7
复制
发表时间：
2022-01
影响因子：
3.4
通讯作者：
Kim YH
中科院分区：
文献类型：
--
作者：
Musiek ACM;Rieger KE;Bagot M;Choi JN;Fisher DC;Guitart J;Haun PL;Horwitz SM;Huen AO;Kwong BY;Lacouture ME;Noor SJ;Rook AH;Seminario-Vidal L;Vermeer MH;Kim YH
与vorinostat相比，ccr4靶向单克隆抗体mogamulizumab已被证明可显著提高复发/难治性蕈样真菌病（MF）和ssamzary综合征（SS）成人患者的无进展生存期和总缓解率。mogamulizumab在MF/SS患者中最常见的不良事件之一是皮疹。由于MF/SS的多变性以及mogamulizumab相关皮疹的多变临床和组织病理学特征，医疗保健提供者可能难以区分皮疹和疾病，并且可能不知道这种通常可控制的不良事件的适当治疗策略。本报告的目的是将已发表文献的结果与多个研究者和机构的经验和建议结合起来，形成临床最佳实践建议，以帮助医疗保健提供者识别和管理mogamulizumab相关皮疹。最佳的管理，包括活检确认和类固醇治疗，需要肿瘤学、皮肤病学和病理学从业人员的多学科方法。
The CCR4-directed monoclonal antibody mogamulizumab has been shown to significantly improve progression-free survival and overall response rate compared with vorinostat in adults with relapsed/refractory mycosis fungoides (MF) and Sézary syndrome (SS). One of the most common adverse events seen with mogamulizumab in MF/SS patients is rash. Because of the protean nature of MF/SS and the variable clinical and histopathological features of mogamulizumab-associated rash, healthcare providers may have difficulty distinguishing rash from disease, and may not be aware of appropriate treatment strategies for this generally manageable adverse event. The objective of this report was to combine results from published literature with experiences and recommendations from multiple investigators and institutions into clinical best practice recommendations to assist healthcare providers in identifying and managing mogamulizumab-associated rash. Optimal management, which includes biopsy confirmation and steroid treatment, requires a multidisciplinary approach among oncology, dermatology, and pathology practitioners.
登录
查看更多内容
影响因子：
5.4
作者：
Al-Banna, Nadia A.;Vaci, Maria;Issekutz, Thomas B.
通讯作者：
Issekutz, Thomas B.
影响因子：
0.3
作者：
Hassel, Jessica C.;Kripp, Melanie;Hofheinz, Ralf-Dieter
通讯作者：
Hofheinz, Ralf-Dieter
影响因子：
6.2
作者：
Demierre, Marie-France;Gan, Stephanie;Miller, Donald R.
通讯作者：
Miller, Donald R.
影响因子：
--
作者：
Breen ID;Brumfiel CM;Patel MH;Rosenthal AC;Rule WG;DiCaudo DJ;Craig FE;Pittelkow MR;Mangold AR
通讯作者：
Mangold AR
影响因子：
2.4
作者：
Foss, Francine M.;Girardi, Michael
通讯作者：
Girardi, Michael