EOSINOPHILIA AND EOSINOPHIL HELMINTHOTOXICITY IN PATIENTS TREATED FOR SCHISTOSOMA-MANSONI INFECTIONS
EOSINOPHILIA AND EOSINOPHIL HELMINTHOTOXICITY IN PATIENTS TREATED FOR SCHISTOSOMA-MANSONI INFECTIONS
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DOI：
10.1016/0035-9203(91)90231-m
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发表时间：
1991-07-01
影响因子：
2.2
通讯作者：
MUGAMBI, M
中科院分区：
文献类型：
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作者：
KIMANI, G;CHUNGE, CN;MUGAMBI, M
在两组相似的15-50岁的患者中，研究了治疗曼氏血吸虫感染后，嗜酸性粒细胞水平和嗜酸性粒细胞介导的抗体依赖的血吸虫细胞毒性的变化。第1组用氢化甘草酮或奥沙米昆治疗，第2组用氢化甘油或吡喹酮治疗。两组患者的嗜酸性粒细胞水平均显著升高。外周血嗜酸粒细胞计数由治疗前的175个/亩-L上升到治疗3周后的745个/亩-L；治疗2组由治疗前的181个/亩-L上升到1066个/亩-L。嗜酸性粒细胞水平的升高与循环中抗成虫抗体的升高呈正相关(r=-0.587，P<0.05)，而与抗卵抗体呈负相关(r=-0.727)。尽管第1组中的一些患者在治疗后嗜酸性粒细胞的蠕虫毒性有所增强(7/15)，但总体上变化并不显著。在使用不同标准抗血吸虫抗体的第2组中，3周时记录的嗜酸性粒细胞杀伤能力低于开始治疗前(t=2.89，P<；0.01)。患者单个核细胞培养上清液中的嗜酸性粒细胞刺激活性与嗜酸性粒细胞水平呈正相关(r=0.582，P<0.01)，但与嗜酸性粒细胞杀伤率无关。MCS活性似乎并未因治疗而增强。这些研究表明，治疗后外周血嗜酸细胞计数增加，但它们杀死血吸虫幼虫的能力是不同的，可能取决于用作抗血吸虫抗体来源的免疫血清。
The changes in eosinophil levels and in eosinophil-mediated antibody-dependent schistosomular cytotoxicity, following treatment for Schistosoma mansoni infections, have been investigated in 2 similar groups of patients aged 15-50 years. Patients in group 1 were treated with either hycanthone or oxamniquine, and those in group 2 with hycanthone or praziquantel. Eosinophil levels were significantly increased in both groups. In group 1 peripheral blood eosinophil counts rose from a mean of 175/mu-l before treatment to 745/mu-l 3 weeks after treatment, and in group 2 from 181/mu-l to 1066/mu-l. The increase in eosinophil levels was positively correlated with a rise in circulating anti-adult worm antibodies (r = -0.587, P < 0.05), whereas a negative correlation was recorded with anti-egg antibodies (r = -0.727). Despite some enhanced eosinophil helminthotoxicity following treatment in some of the individuals in group 1 (7/15), the change overall was not significant. In group 2, in which a different standard anti-schistosomular antibody was used, the eosinophil killing capacity recorded at 3 weeks was lower than that before commencement of treatment (t = 2.89, P < 0.01). The eosinophil stimulating activity, detected in cultured mononuclear cell supernatants (MCS) from individual patients, correlated with eosinophil levels (r = 0.582, P < 0.02) but there was no association with eosinophil killing. MCS activity did not appear to be boosted by treatment. These studies showed that peripheral blood eosinophil counts were increased following treatment, but their ability to kill schistosome larvae is variable and may depend on the immune serum used as the source of anti-schistosomular antibody.