3D-Bioprinted Phantom with Human Skin Phototypes for Biomedical Optics.
3D-Bioprinted Phantom with Human Skin Phototypes for Biomedical Optics.
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用于生物医学光学的具有人体皮肤光型的 3D 生物打印模型。
DOI：
10.1002/adma.202206385
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Jokerst,JesseV
中科院分区：
文献类型：
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作者：
Yim,Wonjun;Zhou,Jiajing;Sasi,Lekshmi;Zhao,Jiayu;Yeung,Justin;Cheng,Yong;Jin,Zhicheng;Johnson,Wade;Xu,Ming;Palma-Chavez,Jorge;Fu,Lei;Qi,Baiyan;Retout,Maurice;Shah,NisargJ;Bae,Jinhye;Jokerst,JesseV
据报道，3D 生物打印的皮肤模仿模型的肤色范围涵盖菲茨帕特里克等级。这些工具可以帮助了解皮肤光型对生物医学光学的影响。制造不同尺寸（70-500 nm）和簇的合成黑色素纳米颗粒来模仿黑素体的光学行为。模型的吸收系数和减少的散射系数与真实的人类皮肤相当。此外，通过光声 (PA) 成像验证模型与真实人类皮肤中黑色素的含量和分布。体模的 PA 信号可以通过以下方式改善：1）增加黑色素大小（3-450 倍），2）增加聚类（2-10.5 倍），3）增加浓度（1.3-8 倍）。然后，使用多种生物医学光学工具（例如 PA、荧光成像和光热疗法）来了解肤色对这些模式的影响。这些定义明确的 3D 生物打印模型可能在转化生物医学光学和减少种族偏见方面具有价值。
3D‐bioprinted skin‐mimicking phantoms with skin colors ranging across the Fitzpatrick scale are reported. These tools can help understand the impact of skin phototypes on biomedical optics. Synthetic melanin nanoparticles of different sizes (70–500 nm) and clusters are fabricated to mimic the optical behavior of melanosome. The absorption coefficient and reduced scattering coefficient of the phantoms are comparable to real human skin. Further the melanin content and distribution in the phantoms versus real human skins are validated via photoacoustic (PA) imaging. The PA signal of the phantom can be improved by: 1) increasing melanin size (3–450‐fold), 2) increasing clustering (2–10.5‐fold), and 3) increasing concentration (1.3–8‐fold). Then, multiple biomedical optics tools (e.g., PA, fluorescence imaging, and photothermal therapy) are used to understand the impact of skin tone on these modalities. These well‐defined 3D‐bioprinted phantoms may have value in translating biomedical optics and reducing racial bias.