Assessing the potential of skin electroporation for the delivery of protein- and gene-based drugs
Assessing the potential of skin electroporation for the delivery of protein- and gene-based drugs
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DOI：
10.1016/s0167-7799(98)01238-4
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发表时间：
1998-10-01
影响因子：
17.3
通讯作者：
Prausnitz, MR
中科院分区：
文献类型：
--
作者：
Banga, AK;Prausnitz, MR
Although transdermal drug delivery has many potential advantages, the permeability of skin to macromolecules is extremely low. However, the application of short, high-voltage pulses to electroporate skin has recently been shown to make it reversibly permeable. A number of studies have demonstrated that electroporation-mediated transdermal delivery of peptides, polysaccharides, oligonucleotides and genes may be possible at clinically relevant rates, leading to the current commercial development of electroporation techniques.
