Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand
Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand
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DOI：
10.1002/ijc.21146
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发表时间：
2005-12-10
影响因子：
6.4
通讯作者：
Miwa, M
中科院分区：
文献类型：
--
作者：
Honjo, S;Srivatanakul, P;Miwa, M
猫尾后睾吸虫（OV）感染与胆管癌有关。OV在泰国东北部很常见，但只有不到10%的居民发展成胆管癌。动物实验表明，单独的OV感染不会引起胆管癌，因此其他环境和遗传因素可能在因果关系中起作用。我们进行了一项以人群为基础的病例对照研究，其中性别、年龄和居住地分别匹配。单独的GSTM1和GSTT1多态性与胆管癌的风险无关，而OV抗体水平升高（ELISA）≥ 0.200是最强的风险指标（与之相比的比值比）。
Infection with Opisthorchis viverrini (OV) is associated with cholangiocarcinoma. OV is common in northeast Thailand, but less than 10% of the inhabitants develop cholangiocarcinoma. Animal experiments suggest that OV infection alone does not cause cholangiocarcinoma, and thus other environmental and genetic factors may play a role in causation. We conducted a population-based case-control study in which sex, age and place of residence were matched individually. Polymorphisms of GSTM1 and GSTT1 alone were not associated with risk for cholangiocarcinoma, while an elevated level of antibodies against OV (ELISA) >= 0.200 was the strongest risk indicator (odds ratio as compared to that