High mobility group HMGI(Y) protein expression in head and neck squamous cell carcinoma
High mobility group HMGI(Y) protein expression in head and neck squamous cell carcinoma
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DOI：
10.1080/00016480600740571
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发表时间：
2007-01-01
影响因子：
1.4
通讯作者：
Shin, Hyung Sik
中科院分区：
文献类型：
--
作者：
Rho, Young Soo;Lim, Young Chang;Shin, Hyung Sik
结论。我们得出结论，高迁移率组I（HMGI(Y)）的表达水平升高与头颈部鳞状细胞癌（HNSCCs）的恶性转化密切相关，并且在HNSCCs中测量HMGI(Y)水平可能有助于作为预后标志物。目标。探讨HMGI在HNSCCs中是否存在过表达，及其作为HNSCCs预后指标的价值。材料和方法。在10例手术切除的非肿瘤组织（正常腭组织）和40例HNSCCs中，采用HMGI(Y)特异性抗体和RT-PCR免疫组织化学方法在蛋白水平上检测HMGI(Y)的表达。我们还评估了HMGI(Y)过表达与临床病理参数的关系，即临床分期、病理分级、颈部淋巴结转移状态、复发率。结果。40例HNSCC标本中有35例（87.5%）通过免疫组化染色观察到HMGI(Y)的表达，而正常粘膜和/或邻近肿瘤组织的粘膜呈阴性或弱阳性染色(p
Conclusion. We conclude that increased expression level of the high mobility group I (HMGI(Y)) is closely associated with malignant transformation in head and neck squamous cell carcinomas (HNSCCs), and the measurement of HMGI(Y) levels in HNSCCs may be useful as a prognostic marker. Objectives. To investigate whether HMGI overexpression is observed in HNSCCs, and its value as a prognostic marker in HNSCCs. Materials and methods. HMGI(Y) expression was determined at the protein level by immunohistochemisty using a HMGI(Y)-specific antibody and RT-PCR in 10 surgically resected specimens of non-neoplastic tissue (normal palatal tissue) and 40 HNSCCs. We also evaluated the association of HMGI(Y) overexpression within clinicopathologic parameters, i.e. clinical stage, pathologic grade, status of cervical lymph node metastasis, recurrence rate. Results. Expression of HMGI(Y) by immunohistochemical staining was observed in 35 of 40 (87.5%) HNSCC samples, whereas normal mucosa and/or the mucosa adjacent to the tumor tissue showed negative or weakly positive staining (p