The dynamics of signal triggering in a gp130-receptor complex.
The dynamics of signal triggering in a gp130-receptor complex.
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DOI：
10.1016/j.str.2007.02.006
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发表时间：
2007-04
期刊：
影响因子：
--
通讯作者：
Fuller S
中科院分区：
文献类型：
--
作者：
Matadeen R;Hon WC;Heath JK;Jones EY;Fuller S
Gp130是几种造血细胞因子的共享信号转导膜相关受体。白细胞介素11(IL-11)-IL-11受体-gp130细胞外复合物的30 Å分辨率冷冻电镜（cryo-EM）结构揭示了这种含gp130信号复合物的结构和动力学。正态分析揭示了一系列构象变化可能在信号触发中起作用。这表明一种协调一致的信号传导机制涉及该复合体的所有组成部分。这可能为细胞因子利用JAK-STAT信号级联传递提供一个通用的信号传递机制。
gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.