Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
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DOI：
10.4049/jimmunol.1203335
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发表时间：
2013-07-15
期刊：
影响因子：
--
通讯作者：
Ma A
中科院分区：
文献类型：
--
作者：
Callahan JA;Hammer GE;Agelides A;Duong BH;Oshima S;North J;Advincula R;Shifrin N;Truong HA;Paw J;Barrera J;DeFranco A;Rosenblum MD;Malynn BA;Ma A
牛皮癣是一种慢性炎症性皮肤病，由环境和遗传因素共同作用引起。Tnip1基因编码ABIN-1(A20结合和核因子κB-1的抑制物)蛋白，与人类银屑病的易感性密切相关。Abin-1是一种广泛表达的泛素结合蛋白，可抑制肿瘤坏死因子和TLR诱导的信号转导。我们在这里报道，缺乏ABIN-1特异性的树突状细胞(DC)的小鼠，ABIN-1Flox CD11c-CRE小鼠，表现出紊乱的免疫动态平衡。Abin-1缺乏的DC在κ配体的作用下，表现出过度的NF、TLR B和MAP激酶信号，并产生比正常细胞多的IL-23。用局部TLR7配体攻击ABIN-1Flox CD11c-Cre小鼠可导致TH17和TcRγδT细胞数量增加，并加剧银屑病样皮损的发展。这些表型被DC特异性缺失的TLR适配器MyD88逆转。这些研究将ABIN-1与IL-23和IL-17联系起来，并提供了ABIN-1调节银屑病易感性的细胞和分子机制。
Psoriasis is a chronic, inflammatory skin disease caused by a combination of environmental and genetic factors. The Tnip1 gene encodes ABIN-1 (A20 Binding and Inhibitor of NFκB-1) protein and is strongly associated with susceptibility to psoriasis in humans. ABIN-1, a widely expressed ubiquitin binding protein, restricts TNF and TLR induced signals. We report here that mice lacking ABIN-1 specifically in dendritic cells (DCs), ABIN-1Flox CD11c-Cre mice, exhibit perturbed immune homeostasis. ABIN-1 deficient DCs display exaggerated NFκB and MAP kinase signaling and produce more IL-23 than normal cells in response to TLR ligands. Challenge of ABIN-1Flox CD11c-Cre mice with topical TLR7 ligand leads to greater numbers of TH17 and TCRγδ T cells and exacerbated development of psoriaform lesions. These phenotypes are reversed by DC-specific deletion of the TLR adaptor MyD88. These studies link ABIN-1 with IL-23 and IL-17, and provide cellular and molecular mechanisms by which ABIN-1 regulates susceptibility to psoriasis.
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影响因子：
30.8
作者：
Nair RP;Duffin KC;Helms C;Ding J;Stuart PE;Goldgar D;Gudjonsson JE;Li Y;Tejasvi T;Feng BJ;Ruether A;Schreiber S;Weichenthal M;Gladman D;Rahman P;Schrodi SJ;Prahalad S;Guthery SL;Fischer J;Liao W;Kwok PY;Menter A;Lathrop GM;Wise CA;Begovich AB;Voorhees JJ;Elder JT;Krueger GG;Bowcock AM;Abecasis GR;Collaborative Association Study of Psoriasis
通讯作者：
Collaborative Association Study of Psoriasis
树突状细胞的组成型消融会破坏CD4 T细胞的自耐力，并导致自发性致命自身免疫性。
DOI：
10.1084/jem.20082394
发表时间：
2009-03-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ohnmacht C;Pullner A;King SB;Drexler I;Meier S;Brocker T;Voehringer D
通讯作者：
Voehringer D
影响因子：
32.4
作者：
Hou, Baidong;Reizis, Boris;DeFranco, Anthony L.
通讯作者：
DeFranco, Anthony L.
影响因子：
64.8
作者：
Oshima, Shigeru;Turer, Emre E.;Callahan, Joseph A.;Chai, Sophia;Advincula, Rommel;Barrera, Julio;Shifrin, Nataliya;Lee, Bettina;Yen, Benjamin;Woo, Tammy;Malynn, Barbara A.;Ma, Averil
通讯作者：
Ma, Averil
DOI：
10.1084/jem.20062648
发表时间：
2007-07-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Caton ML;Smith-Raska MR;Reizis B
通讯作者：
Reizis B