Rapid response to treatment for binge eating disorder
Rapid response to treatment for binge eating disorder
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DOI：
10.1037/0022-006x.74.3.602
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发表时间：
2006-06-01
影响因子：
5.9
通讯作者：
Wilson, G. Terence
中科院分区：
文献类型：
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作者：
Grilo, Carlos M.;Masheb, Robin M.;Wilson, G. Terence
作者检测了108名暴饮暴食障碍(BED)患者的快速反应，他们被随机分配到4种16周治疗中的1种：氟西汀。安慰剂，认知行为疗法(CBT)加氟西汀，或CBT加安慰剂。反应迅速。定义为到第4个治疗周暴饮暴食减少65%或更多，由受试者操作特征曲线确定，快速反应表征了44%的参与者，与参与者的人口统计或基线特征无关。与没有快速反应的参与者相比，快速反应的参与者更有可能实现暴饮暴食的缓解，在进食障碍的精神病理学上有更大的改善，体重减轻也更大，快速反应对CBT和仅接受药物治疗的患者具有不同的预后意义和不同的时间进程。快速反应有助于预测结果，并为BED治疗效果的特异性提供证据。
The authors examined rapid response among 108 patients with binge eating disorder (BED) who were randomly assigned to 1 of 4 16-week treatments: fluoxetine. placebo, cognitive-behavioral therapy (CBT) plus fluoxetine, or CBT plus placebo. Rapid response. defined as 65% or greater reduction in binge eating by the 4th treatment week, was determined by receiver operating characteristic curves', Rapid response characterized 44% of participants and was unrelated to participants' demographic or baseline characteristics. Participants with rapid response were more likely to achieve binge-eating remission, had greater improvements in eating-disorder psychopathology, and had greater weight loss than participants without rapid response, Rapid response had different prognostic significance and distinct time courses for CBT versus pharmacotherapy-only treatments. Rapid response has utility for predicting outcomes and provides evidence for specificity of treatment effects with BED.