Epidemiology of dementia and Alzheimer's disease
Epidemiology of dementia and Alzheimer's disease
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DOI：
10.1097/00019442-199821001-00002
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发表时间：
1998-03-01
影响因子：
7.2
通讯作者：
Hendrie, HC
中科院分区：
文献类型：
--
作者：
Hendrie, HC
北美65岁及以上人群中痴呆症的患病率约为6%-10%，其中阿尔茨海默病(AD)占这些病例的三分之二。如果将较轻的病例包括在内，患病率将翻一番。阿尔茨海默病的致病基因和关联基因现已确定。对非遗传风险因素的研究一直没有那么确定。在所有研究中，只有年龄和痴呆症家族史与AD有关，但假定的保护剂，如雌激素、非类固醇抗炎药(NSAIDs)和维生素E现在正在进行临床试验。
The prevalence of dementia in subjects 65 years and older in North America is approximately 6%-10%, with Alzheimer's disease (AD) accounting for two-thirds of these cases. If milder cases are included the prevalence rates double. Both causative and associative genes for AD have now been identified. The search for nongenetic risk factors has been less conclusive. Only age and family history of dementia are consistently associated with AD in all studies, but putative, protective agents such as estrogen, non-steroidal anti-inflammatory agents (NSAIDs), and vitamin E are now undergoing clinical trials.