Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer
Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer
复制标题
DOI：
10.1158/1078-0432.ccr-05-0964
复制
发表时间：
2006-04-15
影响因子：
11.5
通讯作者：
Zeillinger, R
中科院分区：
文献类型：
--
作者：
Tong, D;Czerwenka, K;Zeillinger, R
目的：kruppel样因子（KLF5）是多种上皮细胞的细胞生长介质。较高的KLF5增加了细胞生长速率并导致表型转化。由于肿瘤细胞增殖与肿瘤进展密切相关，因此与癌症患者的生存密切相关，因此我们想检查KLF5基因表达对乳腺癌患者的预后价值。实验设计：量化90例乳腺癌患者肿瘤组织中KLF5、ER、PR、HER2、MK167基因表达水平，并与患者无病生存期和总生存期相关。分析KLF5与ER、PR、HER2、MK167基因表达的相关性。此外，还将KLF5的表达与临床数据和患者年龄进行比较。结果：KLF5基因表达与无病生存期（单因素分析）和总生存期（单因素和多因素分析）均有统计学显著相关。KLF5高表达的患者无病生存期和总生存期较短，而KLF5低表达的患者生存期较好。此外，KLF5还与HER2和MK167呈正相关，与诊断时患者的年龄负相关。结论：KLF5基因表达与体内细胞增殖直接相关，是乳腺癌患者预后的一个影响因素。KLF5高表达患者的无病生存期和总生存期均短于KLF5低表达患者。此外，KLF5在50岁的患者中表达更高。
Purpose: Kruppel-like factor (KLF5) is a cell growth mediator in various epithelial cells. Higher KLF5 increases cell growth rate and leads to transformed phenotypes. Because tumor cell proliferation is tightly associated with tumor progression, and consequently, with survival of cancer patients, we wanted to examine the prognostic value of KLF5 gene expression for patients with breast cancer.Experimental Design: The gene expression levels of KLF5, ER, PR, HER2, and MK167 were quantified in the tumor tissues of 90 patients with breast cancer and correlated with disease-free survival and overall survival of the patients. The correlations of gene expression between KLF5 and ER, PR, HER2, and MK167 were analyzed. In addition, KLF5 expression was also compared with clinical data and age of patients.Results: Statistically significant correlations were found between gene expression of KLF5 and both disease-free survival (univariate analysis) and overall survival (univariate and multivariate analysis). Patients with higher KLF5 expression had shorter disease-free survival and overall survival time, whereas patients with lower KLF5 expression had better survival. Moreover, KLF5 was also found to be positively correlated with HER2 and MK167, and negatively correlated with age of the patients at diagnosis.Conclusion:The gene expression of KLF5 is directly correlated with cell proliferation in vivo and is a prognostic factor for patients with breast cancer. Patients with higher KLF5 expression have shorter disease-free survival and overall survival than patients with lower KLF5 expression. In addition, KLF5 has higher expression in patients ages 50 years old.