Highly efficient and diastereoselective synthesis of 1,3-oxazolidines featuring a palladium-catalyzed cyclization reaction of 2-butene-1,4-diol derivatives and imines

Highly efficient and diastereoselective synthesis of 1,3-oxazolidines featuring a palladium-catalyzed cyclization reaction of 2-butene-1,4-diol derivatives and imines
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1,3-恶唑烷的高效非对映选择性合成,采用钯催化的 2-丁烯-1,4-二醇衍生物和亚胺的环化反应

DOI:
10.1016/j.tetlet.2010.07.087
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发表时间:
2010-09-29
影响因子:
1.8
通讯作者:
Zhu, Gangguo
Zhu, Gangguo
中科院分区:
化学4区
文献类型:
--
作者:
Chen, Dongxu;Chen, Xiaoyi;Zhu, Gangguo

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A palladium-catalyzed protocol for effective synthesis of 1,3-oxazolidines has been reported. This method is featured by the high diastereoselectivity (dr up to >98/2) and using the readily available 2-butene-1,4-diol derivatives and imines as substrates. (c) 2010 Elsevier Ltd. All rights reserved.