Obesity effects on depression: systematic review of epidemiological studies
Obesity effects on depression: systematic review of epidemiological studies
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DOI：
10.1038/ijo.2008.54
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发表时间：
2008-06-01
影响因子：
4.9
通讯作者：
Baker, M.
中科院分区：
文献类型：
--
作者：
Atlantis, E.;Baker, M.
背景资料：肥胖是心血管疾病负担和过早死亡的一个众所周知的原因，但对心理发病率的影响仍然不确定。本文报告的结果进行了系统的流行病学研究，以确定肥胖是否会导致depression.Methods的回顾：多个数据库进行了搜索的英语语言研究的病因肥胖（暴露变量，分析作为一个有序的类别）抑郁症的结果（因变量，连续或分类）。排除了在儿童和妇女在怀孕或产后的研究，因为是非代表性的横断面研究。EA进行的研究纳入的识别和识别，而重要的研究特征的描述性合成进行独立的由我们。结果：我们回顾了24个约4500潜在的相关研究，4个是前瞻性队列研究和20个横断面研究（10个来自美国）。在所有前瞻性队列研究中报告的效果测量是一致的，并表明肥胖可能会增加未来抑郁症结局（抑郁症的症状或非临床诊断）的几率。在大多数横截面研究报告的措施，从美国支持的假设肥胖和抑郁症的患病率之间的关联结果的妇女，但不是男性，相反，大多数的横截面研究，从人口以外的美国始终未能找到这样的association.Conclusions：总体而言，有一个薄弱的证据支持的假设，肥胖增加抑郁症的发病率的结果。几乎没有高质量的前瞻性队列研究存在，横断面研究占了大量的已发表证据，因此还不能得出确切的因果关系结论。我们的发现保证了关于这个主题的额外的高质量病因学研究。
Background: Obesity is a well-known cause of cardiovascular disease burden and premature death, but effects on psychological morbidity remain uncertain. This article reports findings following a systematic review of epidemiological studies to determine whether obesity causes depression.Methods: Multiple databases were searched for English-language studies of etiology of obesity ( exposure variable, analyzed as an ordered category) on depression outcomes ( dependent variables, continuous or categorical). Studies in children and in women during pregnancy or postpartum were excluded, as were nonrepresentative cross-sectional studies. Searches and identification of studies for inclusion were performed by EA, whereas a descriptive synthesis of important study characteristics was undertaken independently by us.Results: We reviewed 24 out of approximately 4500 potentially relevant studies; 4 were prospective cohort studies and 20 were cross-sectional studies ( 10 from the United States). Effect measures reported in all prospective cohort studies were consistent and suggested that obesity may increase the odds of future depression outcomes (symptoms or nonclinical diagnosis of depression). Effect measures reported in most cross-sectional studies from the United States supported the hypothesized association between obesity and prevalence of depression outcomes for women but not men, in contrast most cross-sectional studies from populations other than the United States consistently failed to find such associations.Conclusions: Overall, there is a weak level of evidence supporting the hypothesis that obesity increases the incidence of depression outcomes. Few high-quality prospective cohort studies exist, and cross-sectional studies account for the vast body of published evidence, and therefore firm conclusions for causality cannot yet be drawn. Our finding warrants additional high-quality etiological research on this topic.