Distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative Parkinsonisms
Distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative Parkinsonisms
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DOI：
10.1016/j.jns.2021.117363
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发表时间：
2021-02-26
影响因子：
4.4
通讯作者：
Yokoyama, Kazumasa
中科院分区：
文献类型：
--
作者：
Takahashi, Ryuichi;Ishii, Kazunari;Yokoyama, Kazumasa
目的：本研究旨在利用多巴胺转运体单光子发射计算机断层扫描图像，确定退行性帕金森病患者多巴胺能和血清素能功能障碍的区域不对称性。材料和方法：本研究纳入213名连续受试者（帕金森病[n = 111]、路易体痴呆[n = 64]、进行性核上性麻痹伴理查德森综合征[n = 18]和健康受试者[n = 20]），他们接受了磁共振成像和i -123标记的2 β -碳甲氧基-3 β -碘苯基)- n -（3-氟丙基）北tropane单光子发射计算机断层扫描/计算机断层扫描。使用归一化特异性结合比图像，我们创建了按体素方向的区域不对称指数图像，以识别退行性帕金森病区域不对称的区域特定模式。结果：与健康对照相比，帕金森病患者黑质纹状体多巴胺能通路区域不对称指数升高，伴路易体痴呆患者双侧尾状体区域不对称指数升高。进行性核上性麻痹患者在大脑皮层-丘脑下通路中表现出明显的区域不对称指数增加。值得注意的是，进行性核上性麻痹的丘脑下核区域不对称指数的增加明显大于帕金森病。结论：本研究揭示了退行性帕金森病患者多巴胺能和血清素能功能障碍的明显区域不对称性。本研究结果强调了视觉诊断在退行性帕金森病中的潜在应用。
Purpose: This study aimed to identify regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative parkinsonisms, using dopamine transporter single-photon emission computed tomography images.Material and methods: This study included 213 consecutive participants (Parkinson's disease [n = 111], dementia with Lewy bodies [n = 64], progressive supranuclear palsy with Richardson's syndrome [n = 18], and healthy participants [n = 20]) who underwent both magnetic resonance imaging and I-123-labelled 2 beta-carbomethoxy-3 beta-iodophenyl)-N-(3-fluoropropyl) nortropane single-photon emission computed tomography/computed tomography. Using normalized specific binding ratio images, we created voxel-wise regional asymmetry index images to identify the regional specific pattern of regional asymmetries in degenerative parkinsonisms.Results: Compared with healthy controls, patients with Parkinson's disease showed a regional asymmetry index increase in the nigrostriatal dopaminergic pathway, and those with dementia with Lewy bodies showed a regional asymmetry index increase confined to the bilateral caudate. Individuals with progressive supranuclear palsy exhibited a distinct regional asymmetry index increase in the pallido-subthalamic pathway. Notably, the regional asymmetry index increase in the subthalamic nucleus was significantly greater in progressive supranuclear palsy than in Parkinson's disease.Conclusion: The current study revealed distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative parkinsonisms. The present findings highlight the potential application of visual diagnosis in degenerative parkinsonisms.