Ultrastructure of adult T-cell leukemia/lymphoma
Ultrastructure of adult T-cell leukemia/lymphoma
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成人T细胞白血病/淋巴瘤的超微结构
DOI：
10.1007/bf02892814
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
M. Kikuchi
中科院分区：
文献类型：
--
作者：
T. Eimoto;T. Mitsui;M. Kikuchi
对日本18例成人T细胞白血病/淋巴瘤（ATLL）进行了电子显微镜分析，并与5例B淋巴瘤和明确的T淋巴瘤组（4例T淋巴母细胞淋巴瘤和2例Sézary综合征）进行了比较。在每种情况下，500个细胞，分类超微结构的细胞大小和核形状，表现出基本上多形性细胞分布在ATLL在显着的对比与单态性的B-“组织细胞”，B-分化良好的淋巴细胞，T-淋巴母细胞性淋巴瘤。一些B淋巴瘤和Sézary综合征也表现出多形性。ATLL病例根据主要细胞和核不规则程度进行分类，其描绘了一系列基于淋巴结的外周T细胞肿瘤，可能包括T免疫母细胞肉瘤、T区淋巴瘤以及多叶T细胞淋巴瘤。与B淋巴瘤相比，ATLL的特征性精细结构包括轻微至显著的核不规则性（以回旋形为主）、大细胞的斑点染色质图案、突出的溶酶体和糖原积聚，以及细胞分布的差异。虽然T淋巴母细胞性淋巴瘤和Sézary综合征具有这些特征，但ATLL与它们的超微结构分化似乎是可能的。
Eighteen cases of adult T-cell leukemia/lymphoma (ATLL) in Japan were analyzed by electron microscopy and compared with 5 cases of B-lymphoma and well-established groups of T-lymphomas (4 cases of T-lymphoblastic lymphoma and 2 cases of Sézary syndrome). Five hundred cells in each case, categorized ultrastructurally as to the cellular size and nuclear shape, showed an essentially pleomorphic cellular distribution in ATLL in remarkable contrast with the monomorphism of B-“histiocytic”, B-well-differentiated lymphocytic, and T-lymphoblastic lymphomas. Some B-lymphomas and Sézary syndrome also showed pleomorphism. Cases of ATLL were classified according to the predominant cells and degree of nuclear irregularity, which delineated a spectrum of node-based, peripheral T-cell neoplasms probably encompassing T-immunoblastic sarcoma, T-zone lymphoma, as well as multilobated T-cell lymphoma. The characteristic fine structure of ATLL, in comparison with that of B-lymphomas, included slight to marked nuclear irregularity with convoluted-shape predominance, a speckled chromatin pattern of the large cells, prominent lysosomes, and glycogen accumulation in addition to the difference in cellular distribution. Although T-lymphoblastic lymphoma and Sézary syndrome shared some of these features, the ultrastructural differentiation of ATLL from them seems to be possible.