Prevalence and related clinical factors of thoracic ossification of the ligamentum flavum-a computed tomography-based cross-sectional study
Prevalence and related clinical factors of thoracic ossification of the ligamentum flavum-a computed tomography-based cross-sectional study
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DOI：
10.1016/j.spinee.2017.08.240
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发表时间：
2018-04-01
期刊：
影响因子：
4.5
通讯作者：
Kim, Young-Hoon
中科院分区：
文献类型：
--
作者：
Kim, Sang-Il;Ha, Kee-Yong;Kim, Young-Hoon
背景文本：胸椎黄韧带骨化症（TOLF）是一种罕见的病理，但它有时会生长并导致严重的神经系统表现。TOLF的流行病学和病因学尚未得到证实。目的：本研究旨在评估TOLF的患病率和临床特征。设计：进行横断面研究。患者样本：所有在我院接受胸部计算机断层扫描（CT）评估肺部疾病或进行医学检查1年的个体组成患者样本。TOLF的存在以及这些发现与胸椎后凸（TK）、后纵韧带骨化（OPLL）、脊髓可用空间（SAC）、年龄、性别、体重指数（BMI）和糖尿病的相关性是结果测量指标。方法：通过CT扫描分析TOLF、TK和并发OPLL的患病率和分布。通过回顾他们的病历，调查了他们的临床特征，包括年龄、性别、BMI和糖尿病。Logistic回归分析确定TOLF的危险因素。结果：共纳入4,999人（男性2,929人，女性2,070人）。在1,090例患者中发现了胸椎黄韧带骨化（男性674例，女性416例）。在592例患者中观察到单个TOLF病变，在498例患者中观察到多个病变。最常累及的节段为T10-T11。TOLF分布呈双峰型，最高峰位于下胸椎（T10-12），次高峰位于T3-T5。TOLF组胸椎后凸为31.5 ° ± 9.5 °，非TOLF组为29.7 ° ± 8.9 °（p
BACKGROUND TEXT: Thoracic ossification of the ligamentum flavum (TOLF) is an uncommon pathology, but it may sometimes grow and cause serious neurologic manifestations. Little has been demonstrated yet about the epidemiology and etiology of TOLF.PURPOSE: This study aimed to estimate the prevalence and clinical characteristics of TOLF.DESIGN: A cross-sectional study was carried out.PATIENT SAMPLE: All individuals who had undergone chest computed tomography (CT) for the evaluation of pulmonary disease or for medical examination for 1 year at our institute comprised the patient sample.OUTCOME MEASURES: Presence of TOLF and the association of these findings with thoracic kyphosis (TK), ossification of posterior longitudinal ligament (OPLL), space available for cord (SAC), age, gender, body mass index (BMI), and diabetes were the outcome measures.METHODS: Prevalence and distribution of TOLF, TK, and concurrent OPLL were analyzed on CT scans. Through reviews of their medical records, clinical characteristics including age, gender, BMI, and diabetes were investigated. Logistic regression analysis was performed to determine the risk factors of TOLF.RESULTS: A total of 4,999 individuals (2,929 men and 2,070 women) were included for the analysis. Thoracic ossification of the ligamentum flavum was found in 1,090 individuals (674 men and 416 women. A single TOLF lesion was noted in 592 individuals and multiple lesions were noted in 498 individuals. The most commonly involved level was T10-T11. Distribution of TOLF showed two peaks: and the highest peak was at the lower thoracic spine (T10-12) and the second highest peak was at T3-T5. Thoracic kyphosis was 31.5 degrees +/- 9.5 degrees in the TOLF group and 29.7 degrees +/- 8.9 degrees in the non-TOLF group (p