FRUCTOSE-INDUCED INSULIN RESISTANCE AND HYPERTENSION IN RATS
FRUCTOSE-INDUCED INSULIN RESISTANCE AND HYPERTENSION IN RATS
复制标题
DOI：
10.1161/01.hyp.10.5.512
复制
发表时间：
1987-11-01
期刊：
影响因子：
8.3
通讯作者：
REAVEN, GM
中科院分区：
文献类型：
--
作者：
HWANG, IS;HO, H;REAVEN, GM
为了确定是否可以通过喂食富含果糖的饮食在正常大鼠中产生高血压，给Sprague-Dawley大鼠喂食正常食物或含有66%果糖（以总热量的百分比计）的饮食约2周。在这一时期结束时，收缩压从124 ± 0.5增加到124 ± 0.5。2至145 .+-. 2（SEM）mm Hg的果糖喂养的大鼠，而在对照组中没有发生变化。此外，高胰岛素血症和高甘油三酯血症与果糖喂养大鼠的高血压有关。可乐定的饮用水抑制果糖引起的高血压，但没有增加血浆胰岛素或甘油三酯浓度似乎在果糖喂养的大鼠。因此，与果糖诱导的高血压相关的代谢变化不太可能继发于交感神经活动的增加。这是否也适用于高血压仍有待澄清。
To determine if hypertension could be produced in normal rats by feeding them a fructose-enriched diet, Sprague-Dawley rats were fed either normal chow or a diet containing 66% fructose as a percentage of total calories for approximately 2 weeks. At the end of this period systolic blood pressure had increased from 124 .+-. 2 to 145 .+-. 2 (SEM) mm Hg in the fructose-fed rats, whereas no change occurred in the control group. In addition, hyperinsulinemia and hypertriglyceridemia were associated with hypertension in fructose-fed rats. The addition of clonidine to the drinking water inhibited fructose-induced hypertension, but not the increase in plasma insulin or triglyceride concentration seem in fructose-fed rats. Thus, the metabolic changes associated with fructose-induced hypertension are unlikely to be secondary to an increase in sympathetic activity. Whether nor not this is also true of the hypertension remains to be clarified.