AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity
AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity
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DOI：
10.1194/jlr.m022897
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发表时间：
2012-07-01
影响因子：
6.5
通讯作者：
Kim, Jae Bum
中科院分区：
文献类型：
--
作者：
Lee, Joo-Won;Choe, Sung Sik;Kim, Jae Bum
在这项研究中，我们证明，腺苷酸活化蛋白激酶（AMPK）与光甘草定的激活，减轻肥胖症和高脂血症的肥胖。在几种肥胖啮齿动物模型中，光甘草定降低了体重和肥胖，同时减少了脂肪细胞的大小。此外，光甘草定改善脂肪肝和甘油三酯和胆固醇的血浆水平。根据这些发现，光甘草定抑制了白色脂肪组织和肝脏中的脂肪生成基因如固醇调节元件结合转录因子（SREBP）-1c、脂肪酸合成酶（FAS）、乙酰辅酶A羧化酶（ACC）和硬脂酰辅酶A去饱和酶（SCD）-1的表达，而它提高了脂肪酸氧化基因如肉毒碱棕榈酰转移酶（CPT）1、酰基辅酶A氧化酶（ACO）和肌肉中的过氧化物酶体增殖物激活受体（PPAR）α。此外，光甘草定增强肌肉和肝脏中AMPK的磷酸化，并通过调节线粒体活性促进脂肪酸氧化。(Jlr)总之，这些数据表明glabridin是一种新型AMPK激活剂，可以在肥胖相关的代谢紊乱中发挥治疗作用。李，J. - W.，S. S.崔，H。Jang，J. Kim，H. W.郑，H。乔，K.- H.郑，S。Tadi，M. G.帕克，T. H.郭先生，J. M.金，D.- H. Hyun和J. B. Kim.光甘草定激活AMPK可改善肥胖症和脂质调节异常J. Lipid Res. 2012. 53：1277-1286。
In this study, we demonstrate that activation of AMP-activated protein kinase (AMPK) with glabridin alleviates adiposity and hyperlipidemia in obesity. In several obese rodent models, glabridin decreased body weight and adiposity with a concomitant reduction in fat cell size. Further, glabridin ameliorated fatty liver and plasma levels of triglyceride and cholesterol. In accordance with these findings, glabridin suppressed the expression of lipogenic genes such as sterol regulatory element binding transcription factor (SREBP)-1c, fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), and stearoyl-CoA desaturase (SCD)-1 in white adipose tissues and liver, whereas it elevated the expression of fatty acid oxidation genes such as carnitine palmitoyl transferase (CPT) 1, acyl-CoA oxidase (ACO), and peroxisome proliferator-activated receptor (PPAR)alpha in muscle. Moreover, glabridin enhanced phosphorylation of AMPK in muscle and liver and promoted fatty acid oxidation by modulating mitochondrial activity.(Jlr) Together, these data suggest that glabridin is a novel AMPK activator that would exert therapeutic effects in obesity-related metabolic disorders.-Lee, J.-W., S. S. Choe, H. Jang, J. Kim, H. W. Jeong, H. Jo, K.-H. Jeong, S. Tadi, M. G. Park, T. H. Kwak,. J. M. Kim, D.-H. Hyun, and J. B. Kim. AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity. J. Lipid Res. 2012. 53: 1277-1286.