Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse
Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse
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DOI：
10.1016/j.bbr.2003.11.010
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发表时间：
2004-08-12
影响因子：
2.7
通讯作者：
Lloyd, KCK
中科院分区：
文献类型：
--
作者：
Golub, MS;Germann, SL;Lloyd, KCK
ErbB 4是神经调节蛋白1生长因子的重要脑受体。开发了一种条件性基因敲除小鼠，其在神经元/神经胶质细胞中缺乏erbB 4基因的两个等位基因，而在其他细胞中缺乏一个等位基因。在一系列行为测试中，将条件突变小鼠与杂合无效（所有组织中有一个无效等位基因和一个野生型等位基因）和野生型对照（无基因缺失）同窝仔进行比较。与野生型对照小鼠相比，条件突变体显示出较低水平的自发运动活动和降低的握力。杂合子无效的组平均得分在这些措施中居中。然而，杂合子无效延迟运动发育和雄性杂合子无效证明改变线索使用在Morris迷宫学习和记忆任务相对于野生型对照和条件突变小鼠。基于对行为数据的更详细分析以及对神经调节蛋白/erbB 4系统在神经系统中的复杂性质和多重作用的考虑，对这些发现进行了解释。(C)2003 Elsevier B. V.保留所有权利。
ErbB4 is an important brain receptor for the neuregulin 1 growth factor. A conditional knock-out mouse was developed lacking both alleles of the erbB4 gene in neurons/glia, and one allele in other cells. The conditional mutant mice were compared to heterozygous null (one null allele and one wildtype allele in all tissues) and wildtype control (no gene deletion) littermates in a battery of behavioral tests. Conditional mutants displayed a lower level of spontaneous motor activity and reduced grip strength compared to wildtype control mice. Group mean scores of heterozygous nulls were intermediate on these measures. However, heterozygous nulls were delayed in motor development and male heterozygous nulls demonstrated altered cue use in a Morris maze learning and memory task relative to both wildtype control and conditional Mutant mice. These findings were interpreted based on more detailed analysis of the behavioral data and considerations of the complex nature and multiple roles of the neuregulin/erbB4 system in the nervous system. (C) 2003 Elsevier B.V. All rights reserved.