The C-Reactive Protein/Albumin Ratio, a Novel Inflammation-Based Prognostic Score, Predicts Outcomes in Patients with Hepatocellular Carcinoma
The C-Reactive Protein/Albumin Ratio, a Novel Inflammation-Based Prognostic Score, Predicts Outcomes in Patients with Hepatocellular Carcinoma
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DOI：
10.1245/s10434-014-4048-0
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发表时间：
2015-03-01
影响因子：
3.7
通讯作者：
Matsushima, Masato
中科院分区：
文献类型：
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作者：
Kinoshita, Akiyoshi;Onoda, Hiroshi;Matsushima, Masato
背景。c反应蛋白/白蛋白（CRP/Alb）比值与脓毒症患者的预后相关。我们探讨了CRP/Alb比值在肝细胞癌（HCC）患者预后中的价值。我们回顾性评估了186例新诊断的HCC患者，并研究了预处理CRP/Alb比值、临床病理参数和总生存期（OS）之间的相关性。进行多变量分析以确定与OS相关的临床病理参数。随后，我们使用曲线下面积（AUC）将CRP/Alb比率与其他基于炎症的预后评分[格拉斯哥预后评分（GPS）、改良GPS （mGPS）和中性粒细胞淋巴细胞比率（NLR）]进行比较，评估其预后价值。CRP/Alb比值的最佳临界值为0.037。升高的CRP/Alb比值（C0.037）与肿瘤进展和肝功能储备降低有关。在多因素分析中，CRP/Alb比值[危险比（HR） 3.394；p
Background. The C-reactive protein/albumin (CRP/Alb) ratio is associated with outcomes in septic patients. We investigated the prognostic value of the CRP/Alb ratio in patients with hepatocellular carcinoma (HCC).Methods. We retrospectively evaluated 186 newly diagnosed HCC patients and investigated the correlations among the pretreatment CRP/Alb ratio, clinicopathological parameters, and overall survival (OS). Multivariate analyses were performed to identify the clinicopathological parameters associated with OS. Subsequently, we evaluated the prognostic value of the CRP/Alb ratio compared with other inflammation-based prognostic scores [Glasgow Prognostic Score (GPS), modified GPS (mGPS), and neutrophil lymphocyte ratio (NLR)] using the area under the curve (AUC).Results. The optimal cutoff level for the CRP/Alb ratio was 0.037. An elevated CRP/Alb ratio (C0.037) was associated with tumor progression and reduced liver functional reserve. In the multivariate analysis, the CRP/Alb ratio [hazard ratio (HR) 3.394; p