Video-rate all-optical ultrasound imaging.
Video-rate all-optical ultrasound imaging.
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DOI：
10.1364/boe.9.003481
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发表时间：
2018-08-01
影响因子：
3.4
通讯作者：
Desjardins AE
中科院分区：
文献类型：
--
作者：
Alles EJ;Noimark S;Maneas E;Zhang EZ;Parkin IP;Beard PC;Desjardins AE
全光学超声成像（利用光产生和检测超声）最近已被证明是一种可行的模式，它本质上对电磁干扰不敏感，并且具有较宽的带宽。先前已经提出了组织的高质量 2D 和 3D 全光学超声图像；然而，迄今为止，较长的采集时间（从几分钟到几小时）阻碍了临床应用。在这里，我们提出了第一个能够对生物组织进行视频速率、实时二维成像的全光学超声成像系统。这是通过使用空间延伸的纳米复合光学超声发生器、高灵敏度光纤声学接收器和偏心照明来实现的，从而使声源表现出最佳方向性。使用快速检流镜对该源进行一维源孔径扫描，从而能够动态合成包含源间隔距离不均匀的空间重叠源的源阵列。由此产生的系统实现了 15 Hz 的持续帧速率、30 dB 的动态范围、至少 6 mm 的穿透深度、75 µm（轴向）x 100 µm（横向）的分辨率，并能够捕获离体颈动脉的搏动动态。
All-optical ultrasound imaging, where ultrasound is generated and detected using light, has recently been demonstrated as a viable modality that is inherently insensitive to electromagnetic interference and exhibits wide bandwidths. High-quality 2D and 3D all-optical ultrasound images of tissues have previously been presented; however, to date, long acquisition times (ranging from minutes to hours) have hindered clinical application. Here, we present the first all-optical ultrasound imaging system capable of video-rate, real-time two-dimensional imaging of biological tissue. This was achieved using a spatially extended nano-composite optical ultrasound generator, a highly sensitive fibre-optic acoustic receiver, and eccentric illumination resulting in an acoustic source exhibiting optimal directivity. This source was scanned across a one-dimensional source aperture using a fast galvo mirror, thus enabling the dynamic synthesis of source arrays comprising spatially overlapping sources at non-uniform source separation distances. The resulting system achieved a sustained frame rate of 15 Hz, a dynamic range of 30 dB, a penetration depth of at least 6 mm, a resolution of 75 µm (axial) by 100 µm (lateral), and enabled the dynamics of a pulsating ex vivo carotid artery to be captured.