A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres
A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres
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DOI：
10.1038/emboj.2009.223
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发表时间：
2009-09-16
期刊：
影响因子：
11.4
通讯作者：
Cooper, Julia Promisel
中科院分区：
文献类型：
--
作者：
Germe, Thomas;Miller, Kyle;Cooper, Julia Promisel
拓扑异构酶II（Top2）的脱连环活性，这是广泛保守的真核结构域内，是必不可少的染色体分离在有丝分裂。然而，目前尚不清楚Top2是否在整个基因组中均匀地执行相同的功能，以及其所有功能是否都依赖于去连锁。在裂殖酵母裂殖酵母中，端粒被Taz1结合，Taz1通过重复的端粒序列促进平滑的复制叉进展。因此，复制叉在taz1 Delta端粒处停滞。这导致在低温下的端粒缠结（
The decatenation activity of topoisomerase II (Top2), which is widely conserved within the eukaryotic domain, is essential for chromosomal segregation in mitosis. It is less clear, however, whether Top2 performs the same function uniformly across the whole genome, and whether all its functions rely on decatenation. In the fission yeast, Schizosaccharomyces pombe, telomeres are bound by Taz1, which promotes smooth replication fork progression through the repetitive telomeric sequences. Hence, replication forks stall at taz1 Delta telomeres. This leads to telomeric entanglements at low temperatures (