High incidence of Crohn's disease in Canterbury, New Zealand: Results of an epidemiologic study
High incidence of Crohn's disease in Canterbury, New Zealand: Results of an epidemiologic study
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DOI：
10.1097/01.mib.0000231572.88806.b9
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发表时间：
2006-10-01
影响因子：
4.9
通讯作者：
Barclay, Murray L.
中科院分区：
文献类型：
--
作者：
Gearry, Richard B.;Richardson, Ann;Barclay, Murray L.
背景：在过去的50年里，炎症性肠病（IBD）在工业化国家呈指数级增长。先前的新西兰研究表明IBD比其他国家更不常见;然而，临床观察表明坎特伯雷IBD的发病率和患病率很高，特别是克罗恩病（CD）。目的：本研究旨在确定坎特伯雷IBD的描述性流行病学。使用多种策略招募的坎特伯雷IBD患者给予知情同意，允许进行临床记录审查，完成问卷调查，作为坎特伯雷IBD项目的一部分，使用标准标准确认病例，并使用捕获-再捕获方法验证招募的完整性。从病例记录中提取人口统计学和表型数据。招募了1420例患者（715例CD，668例溃疡性结肠炎[UC]）（占坎特伯雷IBD患者的91%）。结果：2004年，年龄标准化（世界卫生组织世界标准人群）IBD、CD和UC发病率分别为25.2/100，000/年、16.5/100，000/年和7.6/100，000/年。2005年6月1日，IBD、CD和UC的点患病率分别为308.3/100，000、155.2/100，000和145.0/100，000。CD患者比UC患者更可能为女性（61.4% vs. 47.1%）和更年轻（中位年龄，39.9岁vs. 43.7岁）。结论：坎特伯雷地区IBD的发病率与其他西部地区一样高。CD的发病率和患病率是有史以来报告的最高的，并且高于UC。IBD人群特征在其他方面与其他国家相似。坎特伯雷IBD项目将成为未来基于人群的IBD流行病学和遗传学研究的宝贵工具。
Background: Inflammatory bowel disease (IBD) has increased exponentially in industrialized nations over the last 50 years. Previous New Zealand studies have shown that IBD is less common than in other countries; however, clinical observations suggested a high incidence and prevalence of IBD in Canterbury, particularly Crohn's disease (CD).Aim: This study aimed to determine the descriptive epidemiology of IBD in Canterbury.Methods: Canterbury IBD patients, recruited using multiple strategies, gave informed consent, permission for clinical record review, completed a questionnaire, and were bled for DNA extraction as part of the Canterbury IBD Project. Cases were confirmed using standard criteria, and completeness of recruitment was validated using capture-recapture methods. Demographic and phenotypic data were extracted from case notes. One thousand four hundred twenty patients (715 CD, 668 ulcerative colitis [UC]) were recruited (>91% of Canterbury IBD patients).Results: In 2004, age-standardized (World Health Organization World Standard Population) IBD, CD, and UC incidence rates were 25.2, 16.5, and 7.6/100,000/year, respectively. The IBD, CD, and UC point prevalences on 1 June, 2005 were 308.3, 155.2, and 145.0/ 100,000, respectively. CD patients were more likely than UC patients to be female (61.4% vs. 47.1%) and to be younger (median age, 39.9 years vs. 43.7 years). The percent of IBD patients who were white was 97.5%.Conclusion: IBD is at least as common in Canterbury as in other western regions. CD incidence and prevalence are amongst the highest ever reported and are higher than for UC. IBD population characteristics are otherwise similar to other countries. The Canterbury IBD Project will be a valuable tool for future population-based IBD epidemiology and genetics research.