SMXA-5 mouse as a diabetic model susceptible to feeding a high-fat diet
SMXA-5 mouse as a diabetic model susceptible to feeding a high-fat diet
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DOI：
10.1271/bbb.68.226
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发表时间：
2004-01-01
影响因子：
1.6
通讯作者：
Horio, F
中科院分区：
文献类型：
--
作者：
Kobayashi, M;Io, F;Horio, F
SMXA-5品系是一种新的2型糖尿病小鼠模型，是由非糖尿病SM/J和A/J品系衍生的重组近交系。由于膳食脂肪是糖尿病发展的关键成分，我们比较了SMXA-5，SM/J和A/J菌株之间的葡萄糖耐量和糖尿病相关性状，同时喂养高脂肪饮食10周。高脂饮食喂养的SMXA-5显示血清胰岛素浓度增加。从SMXA-5中的高胰岛素血症判断，该菌株表现出胰岛素抵抗，即外周组织对胰岛素没有反应，这通过高脂肪饮食喂养而加强。当喂食高脂肪饮食5周时，SMXA-5小鼠显示出严重的葡萄糖耐量受损。另一方面，SMJj显示出轻度糖耐量受损，即使在高脂肪饮食喂养10周时也是如此。这些结果表明，SMXA-5可用作对高脂肪饮食敏感的糖尿病模型。
The SMXA-5 strain, a new mouse model for type 2 diabetes, is a recombinant inbred strain derived from non-diabetic SM/J and A/J strains. As dietary fat is a key component in the development of diabetes, we compared the glucose tolerance and diabetes-related traits among the SMXA-5, SM/J, and A/J strains while feeding a high-fat diet for 10 weeks. SMXA-5 fed on a high-fat diet showed an increased serum insulin concentration. Judging from the hyperinsulinemia in SMXA-5, this strain showed insulin resistance, an inability of peripheral tissues to respond to insulin, which was strengthened by feeding with a high-fat diet. When fed on a high-fat diet for 5 weeks, the SMXA-5 mice showed severely impaired glucose tolerance. On the other hand, SMJj showed mildly impaired glucose tolerance, even when fed on a high-fat diet for 10 weeks. These results indicate that SMXA-5 would be available for use as a diabetic model susceptible to a high-fat diet.