Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat
Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat
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DOI：
10.1080/00016480500540519
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发表时间：
2006-12-01
影响因子：
1.4
通讯作者：
Ruan, Runsheng
中科院分区：
文献类型：
--
作者：
Duan, Maoli;Chen, Zhiqiang;Ruan, Runsheng
结论生理和形态学评估表明，低剂量和长期的caroverine给药可能是一种新的途径，以防止脉冲噪声引起的听力损失。背景虽然脉冲噪声导致听力损失的确切机制尚不清楚，但越来越多的证据表明，内毛细胞产生的活性氧（ROS）增加和释放的过量谷氨酸会导致毛细胞损失，从而导致听力损失。Caroverine是内耳中两种谷氨酸受体α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）和N-甲基- D-天冬氨酸（NMDA）受体的拮抗剂，也是一种抗氧化剂.材料和方法。在本研究中，使用渗透泵皮下给药卡洛维林。通过连续、长期和低剂量的药物给药，这种递送具有避免全身副作用的优点。结果结果表明，caroverine对脉冲噪声性耳蜗损伤有明显的保护作用。
Conclusion. Physiological and morphological assessments indicated that low- dose and long- term caroverine delivery might be a new approach to protect against impulse noise- induced hearing loss. Background. Although the exact mechanisms by which impulse noise causes hearing loss are still unclear, there is accumulating evidence that increased reactive oxygen species ( ROS) production and excessive glutamate released from the inner hair cells lead to hair cell loss and consequently hearing loss. Caroverine is an antagonist of two glutamate receptors, alpha- amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic acid ( AMPA) and N- methyl- D- aspartate ( NMDA) receptors in the inner ear, as well as an antioxidant. Materials and methods. In this study, caroverine was delivered subcutaneously using an osmotic pump. This kind of delivery has the advantage, via continuous, long- term and low dose drug administration, of avoiding systemic side effects. Results. It was shown that caroverine could significantly protect the cochlea against impulse noise trauma.