Advanced antisense therapies for postexposure protection against lethal filovirus infections
Advanced antisense therapies for postexposure protection against lethal filovirus infections
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DOI：
10.1038/nm.2202
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发表时间：
2010-09-01
期刊：
影响因子：
82.9
通讯作者：
Bavari, Sina
中科院分区：
文献类型：
--
作者：
Warren, Travis K.;Warfield, Kelly L.;Bavari, Sina
目前，没有疫苗或治疗剂被许可对抗埃博拉病毒或马尔堡病毒，高致病性丝状病毒是病毒性出血热的病原体。在此，我们表明，通过感染后30-60分钟开始的各种给药策略递送的带正电荷的磷酰二胺吗啉代寡聚物（PMOplus）的施用保护>60%的恒河猴对抗致死性扎伊尔埃博拉病毒（ZEBOV），并且保护100%的食蟹猴对抗维多利亚湖马尔堡病毒（MARV）感染。PMOplus可用于治疗人类中的这些和其他高致病性病毒。
Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show that administration of positively charged phosphorodiamidate morpholino oligomers (PMOplus), delivered by various dosing strategies initiated 30-60 min after infection, protects >60% of rhesus monkeys against lethal Zaire Ebola virus (ZEBOV) and 100% of cynomolgus monkeys against Lake Victoria Marburg virus (MARV) infection. PMOplus may be useful for treating these and other highly pathogenic viruses in humans.