Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
复制标题
DOI：
10.1038/nchembio.1735
复制
发表时间：
2015-03
影响因子：
14.8
通讯作者：
Wilson, David M.
中科院分区：
文献类型：
--
作者：
Lewis, Huw D.;Liddle, John;Coote, Jim E.;Atkinson, Stephen J.;Barker, Michael D.;Bax, Benjamin D.;Bicker, Kevin L.;Bingham, Ryan P.;Campbell, Matthew;Chen, Yu Hua;Chung, Chun-Wa;Craggs, Peter D.;Davis, Rob P.;Eberhard, Dirk;Joberty, Gerard;Lind, Kenneth E.;Locke, Kelly;Maller, Claire;Martinod, Kimberly;Patten, Chris;Polyakova, Oxana;Rise, Cecil E.;Ruediger, Martin;Sheppard, Robert J.;Slade, Daniel J.;Thomas, Pamela;Thorpe, Jim;Yao, Gang;Drewes, Gerard;Wagner, Denisa D.;Thompson, Paul R.;Prinjha, Rab K.;Wilson, David M.
通过小鼠的临床遗传学和基因破坏，PAD4与自身免疫、心血管和肿瘤疾病的发病机制密切相关。新型的选择性PAD4抑制剂与缺钙形式的PAD4酶结合，首次验证了人和小鼠PAD4在组蛋白瓜氨酸化和中性粒细胞细胞外TRAP形成中的关键酶作用。现在可以探索PAD4抑制剂的治疗潜力。
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases, through clinical genetics and gene disruption in mice. Novel, selective PAD4 inhibitors binding to a calcium-deficient form of the PAD4 enzyme have, for the first time, validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation. The therapeutic potential of PAD4 inhibitors can now be explored.
登录
查看更多内容
DOI：
10.1084/jem.20100239
发表时间：
2010-08-30
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Li P;Li M;Lindberg MR;Kennett MJ;Xiong N;Wang Y
通讯作者：
Wang Y
影响因子：
7.3
作者：
Causey, Corey P.;Jones, Justin E.;Slack, Jessica L.;Kamei, Daisuke;Jones, Larry E., Jr.;Subramanian, Venkataraman;Knuckley, Bryan;Ebrahimi, Pedram;Chumanevich, Alexander A.;Luo, Yuan;Hashimoto, Hiroshi;Sato, Mamoru;Hofseth, Lorne J.;Thompson, Paul R.
通讯作者：
Thompson, Paul R.
影响因子：
5.3
作者：
Li, Pingxin;Yao, Hongjie;Wang, Yanming
通讯作者：
Wang, Yanming
DOI：
10.1107/s0907444909052925
发表时间：
2010-02
期刊：
Acta crystallographica. Section D, Biological crystallography
影响因子：
--
作者：
Adams PD;Afonine PV;Bunkóczi G;Chen VB;Davis IW;Echols N;Headd JJ;Hung LW;Kapral GJ;Grosse-Kunstleve RW;McCoy AJ;Moriarty NW;Oeffner R;Read RJ;Richardson DC;Richardson JS;Terwilliger TC;Zwart PH
通讯作者：
Zwart PH
影响因子：
2.9
作者：
Knuckley, Bryan;Causey, Corey P.;Jones, Justin E.;Bhatia, Monica;Dreyton, Christina J.;Osborne, Tanesha C.;Takahara, Hidenari;Thompson, Paul R.
通讯作者：
Thompson, Paul R.