INVITRO CULTIVATION OF THE EXOERYTHROCYTIC STAGE OF PLASMODIUM-BERGHEI IN A HEPATOMA-CELL LINE
INVITRO CULTIVATION OF THE EXOERYTHROCYTIC STAGE OF PLASMODIUM-BERGHEI IN A HEPATOMA-CELL LINE
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DOI：
10.4269/ajtmh.1983.32.682
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
SCHWARTZ, AL
中科院分区：
文献类型：
--
作者：
HOLLINGDALE, MR;LELAND, P;SCHWARTZ, AL
当接种伯氏疟原虫的子孢子时，来源于人肝脏的肝癌细胞系（HepG 2-A16）支持红细胞外期的完整无性发育周期。寄生虫在肝细胞中与体内寄生虫相似。裂殖子亚接种到小鼠中诱导红细胞感染。
When inoculated with sporozoites of P. berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of the exoerythrocytic stage. Parasites resembled parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.