TREATMENT OF INTRAOCULAR PROLIFERATION WITH INTRAVITREAL INJECTION OF TRIAMCINOLONE ACETONIDE
TREATMENT OF INTRAOCULAR PROLIFERATION WITH INTRAVITREAL INJECTION OF TRIAMCINOLONE ACETONIDE
复制标题
DOI：
10.1016/s0002-9394(14)75196-7
复制
发表时间：
1980-01-01
影响因子：
4.2
通讯作者：
MACHEMER, R
中科院分区：
文献类型：
--
作者：
TANO, Y;CHANDLER, D;MACHEMER, R
The inhibitory effect of triamcinolone acetonide on experimental intraocular proliferation was studied. Autotransplantation of fibroblasts from rabbit rump skin into the vitreous cavity caused intravitreal strand formation and traction retinal detachment in 36 of 43 eyes (84%) over a period of 3 mo. A single intravitreal injection of 1 mg of triamcinolone acetonide inhibited fibroblast growth and significantly reduced the number of retinal detachments in 15 of 44 eyes (34%). Retinal neovascularization caused by fibrous strands coming into contact with vascularized retina was reduced by triamcinolone acetonide (31 of 43 control eyes [72%] vs. 8 of 44 treated eyes [18%]). Intravitreal corticosteroid therapy may be an important adjunct to the therapy of perforating injuries and massive periretinal proliferation.
